Autoimmunity against vasoactive neuropeptides in retinal blood vessels may cause retinopathy by disrupting local blood flow regulation — a novel immunological theory for vascular retinal diseases.
Key findingAutoimmune targeting of vasoactive neuropeptides (VIP, PACAP) in retinal vessels may cause retinopathy through impaired local blood flow autoregulatio
What the researchers found
Autoimmune targeting of vasoactive neuropeptides (VIP, PACAP) in retinal vessels may cause retinopathy through impaired local blood flow autoregulation — proposing neuropeptide autoimmunity as a mechanism for vascular retinal diseases including diabetic retinopathy.
Why it matters
Relevant for neuropeptides, eye-health, inflammation.
How the study worked
review study.
What this study cannot tell us
See abstract.
How to read the evidence
preliminary evidence.
When this study was published
Published in 2008.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Does autoimmunity of endogenous vasoactive neuropeptides cause retinopathy in humans?
Medical hypotheses, 70(1), 137-40
Citation
Staines, Donald R. (2008). Does autoimmunity of endogenous vasoactive neuropeptides cause retinopathy in humans?. Medical hypotheses, 70(1), 137-40.