Are MS and ALS Caused by Autoimmunity Against the Brain's Own Neuropeptides?
Autoimmunity against endogenous vasoactive neuropeptides (VIP, PACAP, CGRP) is proposed as a pathogenic mechanism for MS and ALS, with evidence of anti-neuropeptide antibodies in these patients.
Quick Facts
What This Study Found
Autoimmune attack on endogenous vasoactive neuropeptides (VIP, PACAP, CGRP) is proposed as a pathogenic mechanism for MS and ALS, with detection of anti-neuropeptide antibodies and correlation with disease activity — neuropeptide autoimmunity as neurodegeneration cause.
Key Numbers
How They Did This
review study.
Why This Research Matters
Relevant for neuropeptides, neuroprotection, immune-function.
The Bigger Picture
Advances peptide research.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding Autoimmune attack on endogenous vasoactive neuropeptides (VIP, PACAP, CGRP) is proposed as a pathogenic mechanism for MS and ALS, with detection of an
- Evidence Grade:
- preliminary evidence.
- Study Age:
- Published in 2008.
- Original Title:
- Are multiple sclerosis and amyotrophic lateral sclerosis autoimmune disorders of endogenous vasoactive neuropeptides?
- Published In:
- Medical hypotheses, 70(2), 413-8 (2008)
- Authors:
- Staines, Donald R(3)
- Database ID:
- RPEP-01423
Evidence Hierarchy
Summarizes existing research on a topic.
What do these levels mean? →Frequently Asked Questions
What was studied?
Are MS and ALS Caused by Autoimmunity Against the Brain's Own Neuropeptides?
What was found?
Autoimmunity against endogenous vasoactive neuropeptides (VIP, PACAP, CGRP) is proposed as a pathogenic mechanism for MS and ALS, with evidence of anti-neuropeptide antibodies in these patients.
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Cite This Study
https://rethinkpeptides.com/research/RPEP-01423APA
Staines, Donald R. (2008). Are multiple sclerosis and amyotrophic lateral sclerosis autoimmune disorders of endogenous vasoactive neuropeptides?. Medical hypotheses, 70(2), 413-8.
MLA
Staines, Donald R. "Are multiple sclerosis and amyotrophic lateral sclerosis autoimmune disorders of endogenous vasoactive neuropeptides?." Medical hypotheses, 2008.
RethinkPeptides
RethinkPeptides Research Database. "Are multiple sclerosis and amyotrophic lateral sclerosis aut..." RPEP-01423. Retrieved from https://rethinkpeptides.com/research/staines-2008-are-multiple-sclerosis-and
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.