Oat protein peptides stimulate appetite-suppressing hormone CCK through calcium-sensing receptor signaling
Four novel peptides from oat protein hydrolysate, especially QGDVVALPA, stimulate CCK secretion through calcium-sensing receptor/Gq/CaMKII signaling, with intragastric OPH administration increasing plasma CCK in mice.
Quick Facts
What This Study Found
4 novel CCK-stimulating peptides identified from oat. QGDVVALPA most potent. Mechanism: calcium-sensing receptor → Gq → intracellular Ca²⁺ → CaMKII → CCK secretion. OPH increased plasma CCK in mice.
Key Numbers
How They Did This
Simulated GI digestion, mouse intragastric administration, SEC and LC-MS/MS peptide identification, STC-1 cell CCK secretion assays, receptor inhibition studies.
Why This Research Matters
Natural appetite control through food-derived peptides could complement pharmacological weight management. Identifying specific peptides and their signaling mechanism enables targeted functional food development.
The Bigger Picture
Food-derived bioactive peptides that naturally stimulate satiety hormones bridge the gap between nutrition and pharmacotherapy, offering a dietary approach to appetite control that could complement GLP-1 drugs.
What This Study Doesn't Tell Us
Mouse study. Specific peptide doses in food matrix unclear. Bioavailability of individual peptides in humans unknown. CCK stimulation is one of many satiety mechanisms.
Questions This Raises
- ?Could QGDVVALPA be developed as a functional food supplement for weight management?
- ?Do these peptides survive human digestion to reach gut endocrine cells?
- ?Would combining oat peptides with GLP-1 drugs enhance satiety?
Trust & Context
- Key Stat:
- QGDVVALPA = top CCK stimulator Novel oat peptide stimulates the appetite-suppressing hormone CCK through a defined receptor-signaling pathway, potentially enabling natural appetite control foods
- Evidence Grade:
- Preclinical with in vivo validation. Well-defined mechanism. Translational potential for functional foods.
- Study Age:
- Published in 2025.
- Original Title:
- Novel Cholecystokinin Secretion-Stimulating Peptides from Oat Protein Hydrolysate: Sequence Identification and Insight into the Mechanism of Action.
- Published In:
- Journal of agricultural and food chemistry, 73(18), 10998-11006 (2025)
- Authors:
- Song, Hongdong, Xue, Lei, Fu, Qiuyun, Wang, Haiyan, Cao, Hongwei, Huang, Kai, Guan, Xiao
- Database ID:
- RPEP-13647
Evidence Hierarchy
Frequently Asked Questions
Can eating oats help control appetite?
This study found specific peptides released during oat protein digestion stimulate CCK—a hormone that tells your brain you are full. The most potent peptide, QGDVVALPA, activates a defined signaling pathway in gut cells. This provides scientific backing for oats' traditional reputation as a satisfying food.
Could this lead to appetite-control supplements?
Potentially. Now that the specific peptides and their mechanism are identified, they could be developed into functional food ingredients or supplements that naturally boost satiety. This would offer a dietary complement to weight management medications.
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Cite This Study
https://rethinkpeptides.com/research/RPEP-13647APA
Song, Hongdong; Xue, Lei; Fu, Qiuyun; Wang, Haiyan; Cao, Hongwei; Huang, Kai; Guan, Xiao. (2025). Novel Cholecystokinin Secretion-Stimulating Peptides from Oat Protein Hydrolysate: Sequence Identification and Insight into the Mechanism of Action.. Journal of agricultural and food chemistry, 73(18), 10998-11006. https://doi.org/10.1021/acs.jafc.5c00727
MLA
Song, Hongdong, et al. "Novel Cholecystokinin Secretion-Stimulating Peptides from Oat Protein Hydrolysate: Sequence Identification and Insight into the Mechanism of Action.." Journal of agricultural and food chemistry, 2025. https://doi.org/10.1021/acs.jafc.5c00727
RethinkPeptides
RethinkPeptides Research Database. "Novel Cholecystokinin Secretion-Stimulating Peptides from Oa..." RPEP-13647. Retrieved from https://rethinkpeptides.com/research/song-2025-novel-cholecystokinin-secretionstimulating-peptides
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.