Ghrelin inhibited gastric acid secretion in rats through GHS-R1a, counterintuitively showing the hunger hormone also protects the stomach from acid — dual function of appetite stimulation and gastroprotection.
Key findingGhrelin inhibited pentagastrin-stimulated gastric acid secretion through GHS-R1a in rats, demonstrating that the appetite-stimulating hormone simultan
What the researchers found
Ghrelin inhibited pentagastrin-stimulated gastric acid secretion through GHS-R1a in rats, demonstrating that the appetite-stimulating hormone simultaneously protects the stomach from acid damage — an integrated eat-and-protect function.
Why it matters
Relevant for ghrp, gut-healing.
How the study worked
animal-study study on ghrp, gut-healing.
What this study cannot tell us
See abstract.
How to read the evidence
preliminary evidence.
When this study was published
Published in 2006.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Evidence for a role of the GHS-R1a receptors in ghrelin inhibition of gastric acid secretion in the rat.
Journal of neuroendocrinology, 18(2), 122-8
Citation
Sibilia, V; Muccioli, G; Deghenghi, R; Pagani, F; De Luca, V; Rapetti, D; Locatelli, V; Netti, C. (2006). Evidence for a role of the GHS-R1a receptors in ghrelin inhibition of gastric acid secretion in the rat.. Journal of neuroendocrinology, 18(2), 122-8.