Lower human defensin 5 in elderly people compared to middle-aged is associated with differences in the intestinal microbiota composition: the DOSANCO Health Study.
Quick Facts
What This Study Found
Elderly individuals had significantly lower HD5 levels (r = -0.307, p < 0.001) and different gut microbiota composition.
Key Numbers
How They Did This
Fecal samples were collected from 196 healthy Japanese participants, and HD5 concentrations were measured to assess correlations with gut microbiota.
Why This Research Matters
Understanding the relationship between defensin levels and gut microbiota can help explain age-related health risks. This research may guide future strategies for improving gut health in the elderly.
What This Study Doesn't Tell Us
The study is limited to a specific population (Japanese individuals) and may not be generalizable to other ethnic groups.
Trust & Context
- Original Title:
- Lower human defensin 5 in elderly people compared to middle-aged is associated with differences in the intestinal microbiota composition: the DOSANCO Health Study.
- Published In:
- GeroScience, 44(2), 997-1009 (2022)
- Authors:
- Shimizu, Yu(2), Nakamura, Kiminori(6), Kikuchi, Mani(2), Ukawa, Shigekazu, Nakamura, Koshi, Okada, Emiko, Imae, Akihiro, Nakagawa, Takafumi, Yamamura, Ryodai, Tamakoshi, Akiko, Ayabe, Tokiyoshi
- Database ID:
- RPEP-06497
Evidence Hierarchy
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Cite This Study
https://rethinkpeptides.com/research/RPEP-06497APA
Shimizu, Yu; Nakamura, Kiminori; Kikuchi, Mani; Ukawa, Shigekazu; Nakamura, Koshi; Okada, Emiko; Imae, Akihiro; Nakagawa, Takafumi; Yamamura, Ryodai; Tamakoshi, Akiko; Ayabe, Tokiyoshi. (2022). Lower human defensin 5 in elderly people compared to middle-aged is associated with differences in the intestinal microbiota composition: the DOSANCO Health Study.. GeroScience, 44(2), 997-1009. https://doi.org/10.1007/s11357-021-00398-y
MLA
Shimizu, Yu, et al. "Lower human defensin 5 in elderly people compared to middle-aged is associated with differences in the intestinal microbiota composition: the DOSANCO Health Study.." GeroScience, 2022. https://doi.org/10.1007/s11357-021-00398-y
RethinkPeptides
RethinkPeptides Research Database. "Lower human defensin 5 in elderly people compared to middle-..." RPEP-06497. Retrieved from https://rethinkpeptides.com/research/shimizu-2022-lower-human-defensin-5
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.