A Venomics Approach to the Identification and Characterization of Bioactive Peptides From Animal Venoms for Colorectal Cancer Therapy: Protocol for a Proof-of-Concept Study.
Quick Facts
What This Study Found
Protocol describes high-throughput screening of 2,500 peptides from 20 animal venoms against colorectal cancer cell lines, with plans to isolate and characterize the most potent anti-CRC peptides.
Key Numbers
2,500 peptides; 20 venoms; 3 CRC cell lines; 2 control cell lines; MTT assay; top 3 venoms for peptide isolation
How They Did This
Proof-of-concept protocol. Will screen 2,500 peptides from 20 venoms using MTT cytotoxicity assay against 3 CRC cell lines and 2 control cell lines. Top 3 venoms will be further fractionated to identify specific anti-cancer peptides.
Why This Research Matters
Colorectal cancer is a leading cause of cancer death. Current treatments have significant side effects. Venom-derived peptides could provide targeted cancer-killing agents with different mechanisms than existing drugs.
What This Study Doesn't Tell Us
Protocol only. No results available. Cell line screening does not predict clinical efficacy. The specificity of venom peptides in living organisms may differ from cell culture results.
Trust & Context
- Original Title:
- A Venomics Approach to the Identification and Characterization of Bioactive Peptides From Animal Venoms for Colorectal Cancer Therapy: Protocol for a Proof-of-Concept Study.
- Published In:
- JMIR research protocols, 10(12), e31128 (2021)
- Database ID:
- RPEP-05753
Evidence Hierarchy
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-05753APA
Shahzadi, Syeda Kiran; Karuvantevida, Noushad; Banerjee, Yajnavalka. (2021). A Venomics Approach to the Identification and Characterization of Bioactive Peptides From Animal Venoms for Colorectal Cancer Therapy: Protocol for a Proof-of-Concept Study.. JMIR research protocols, 10(12), e31128. https://doi.org/10.2196/31128
MLA
Shahzadi, Syeda Kiran, et al. "A Venomics Approach to the Identification and Characterization of Bioactive Peptides From Animal Venoms for Colorectal Cancer Therapy: Protocol for a Proof-of-Concept Study.." JMIR research protocols, 2021. https://doi.org/10.2196/31128
RethinkPeptides
RethinkPeptides Research Database. "A Venomics Approach to the Identification and Characterizati..." RPEP-05753. Retrieved from https://rethinkpeptides.com/research/shahzadi-2021-a-venomics-approach-to
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.