Formulation of pH-responsive nanoplexes based on an antimicrobial peptide and sodium alginate for targeted delivery of vancomycin against resistant bacteria.
Quick Facts
What This Study Found
pH-responsive nanoplexes combining a plant antimicrobial peptide with vancomycin showed 2-fold stronger activity against MRSA, 5-fold better biofilm eradication, and 4-5 fold reduced bacterial burden in kidneys, liver, and blood of mice with MRSA infection.
Key Numbers
Particle size 159.5 nm. Encapsulation efficiency 82.34%. 2-fold enhanced activity vs S. aureus and MRSA. 5-fold greater MRSA biofilm eradication. In vivo: 5-fold reduction in kidney MRSA, 4-fold in liver and blood. pH-accelerated VCM release at acidic pH.
How They Did This
Formulated nanoplexes from plant AMP and sodium alginate loaded with vancomycin. Characterized size, zeta potential, encapsulation, pH-responsive release. In vitro: MIC, biofilm eradication. In vivo: MRSA systemic infection in mice, organ bacterial burden, inflammation markers.
Why This Research Matters
MRSA is a leading cause of hospital deaths. This nanoparticle delivery system makes vancomycin far more effective by combining it with an antimicrobial peptide in a pH-triggered release system.
What This Study Doesn't Tell Us
Specific plant AMP not named in abstract. Mouse model may not reflect human MRSA infection. Toxicity profile needs more characterization. Manufacturing scalability not addressed.
Trust & Context
- Original Title:
- Formulation of pH-responsive nanoplexes based on an antimicrobial peptide and sodium alginate for targeted delivery of vancomycin against resistant bacteria.
- Published In:
- Biological chemistry, 406(8-9), 369-389 (2025)
- Authors:
- Shahin, Shourok, Omolo, Calvin A, Elhassan, Eman, Ismail, Eman A, Farukh, Sania, Govender, Jasoda, Faya, Mbuso, Govender, Thirumala
- Database ID:
- RPEP-13536
Evidence Hierarchy
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-13536APA
Shahin, Shourok; Omolo, Calvin A; Elhassan, Eman; Ismail, Eman A; Farukh, Sania; Govender, Jasoda; Faya, Mbuso; Govender, Thirumala. (2025). Formulation of pH-responsive nanoplexes based on an antimicrobial peptide and sodium alginate for targeted delivery of vancomycin against resistant bacteria.. Biological chemistry, 406(8-9), 369-389. https://doi.org/10.1515/hsz-2025-0142
MLA
Shahin, Shourok, et al. "Formulation of pH-responsive nanoplexes based on an antimicrobial peptide and sodium alginate for targeted delivery of vancomycin against resistant bacteria.." Biological chemistry, 2025. https://doi.org/10.1515/hsz-2025-0142
RethinkPeptides
RethinkPeptides Research Database. "Formulation of pH-responsive nanoplexes based on an antimicr..." RPEP-13536. Retrieved from https://rethinkpeptides.com/research/shahin-2025-formulation-of-phresponsive-nanoplexes
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.