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Bioactivity of Marine-Derived Peptides and Proteins: A Review.

Comprehensive ReviewNot Applicable (Review) evidence

This record provides bibliographic details and links to the original research. An editorial study breakdown is not available.

What the researchers found

Marine-derived peptides (3-40 amino acids) from fish, algae, mollusks, and crustaceans show antioxidant, antihypertensive, antidiabetic, antimicrobial, anti-inflammatory, and anticancer activities. Production scale-up, stability, and bioavailability remain major challenges.

Why it matters

The ocean is a largely untapped source of bioactive peptides. This review maps the landscape of marine peptide bioactivities and identifies the gaps between discovery and commercial application.

The numbers in context

Peptides typically 3-40 amino acids (most commonly 2-20). Sources: fish, algae, mollusks, crustaceans, microbes, marine by-products. Activities: antioxidant, antihypertensive, antidiabetic, antimicrobial, anti-inflammatory, anticoagulant, anticancer, immunoregulatory, wound-healing.

How the study worked

Comprehensive review of marine-derived peptide and protein bioactivities, extraction methods (enzymatic hydrolysis, ultrafiltration, HPLC, molecular docking), and industrial application challenges.

Who was studied

Not applicable (review of marine bioactive peptide research)

What this study cannot tell us

Review article. Most bioactivities demonstrated in vitro. Few marine peptides have reached clinical trials. Bioavailability and stability issues are largely unresolved.

Read the original research

Bioactivity of Marine-Derived Peptides and Proteins: A Review.

Marine drugs, 23(4)

Citation

Shahidi, Fereidoon; Saeid, Abu. (2025). Bioactivity of Marine-Derived Peptides and Proteins: A Review.. Marine drugs, 23(4). https://doi.org/10.3390/md23040157