Bioactivity of Marine-Derived Peptides and Proteins: A Review.
Quick Facts
What This Study Found
Marine-derived peptides (3-40 amino acids) from fish, algae, mollusks, and crustaceans show antioxidant, antihypertensive, antidiabetic, antimicrobial, anti-inflammatory, and anticancer activities. Production scale-up, stability, and bioavailability remain major challenges.
Key Numbers
Peptides typically 3-40 amino acids (most commonly 2-20). Sources: fish, algae, mollusks, crustaceans, microbes, marine by-products. Activities: antioxidant, antihypertensive, antidiabetic, antimicrobial, anti-inflammatory, anticoagulant, anticancer, immunoregulatory, wound-healing.
How They Did This
Comprehensive review of marine-derived peptide and protein bioactivities, extraction methods (enzymatic hydrolysis, ultrafiltration, HPLC, molecular docking), and industrial application challenges.
Why This Research Matters
The ocean is a largely untapped source of bioactive peptides. This review maps the landscape of marine peptide bioactivities and identifies the gaps between discovery and commercial application.
What This Study Doesn't Tell Us
Review article. Most bioactivities demonstrated in vitro. Few marine peptides have reached clinical trials. Bioavailability and stability issues are largely unresolved.
Trust & Context
- Original Title:
- Bioactivity of Marine-Derived Peptides and Proteins: A Review.
- Published In:
- Marine drugs, 23(4) (2025)
- Authors:
- Shahidi, Fereidoon, Saeid, Abu
- Database ID:
- RPEP-13534
Evidence Hierarchy
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-13534APA
Shahidi, Fereidoon; Saeid, Abu. (2025). Bioactivity of Marine-Derived Peptides and Proteins: A Review.. Marine drugs, 23(4). https://doi.org/10.3390/md23040157
MLA
Shahidi, Fereidoon, et al. "Bioactivity of Marine-Derived Peptides and Proteins: A Review.." Marine drugs, 2025. https://doi.org/10.3390/md23040157
RethinkPeptides
RethinkPeptides Research Database. "Bioactivity of Marine-Derived Peptides and Proteins: A Revie..." RPEP-13534. Retrieved from https://rethinkpeptides.com/research/shahidi-2025-bioactivity-of-marinederived-peptides
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.