Tirzepatide-Induced Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) Presenting With Seizures.
Quick Facts
What This Study Found
A 63-year-old woman developed severe hyponatremia (sodium 122 mmol/L) and seizures from SIADH just 4 days after starting tirzepatide for weight loss. She had no prior medical history. Stopping tirzepatide and fluid restriction resolved the condition.
Key Numbers
63-year-old woman. No past medical history. Tonic-clonic seizures 4 days after starting tirzepatide. Serum sodium 122 mmol/L. Low serum osmolality. High urine osmolality and urine sodium consistent with SIADH. Full recovery after discontinuation and fluid restriction.
How They Did This
Single case report with clinical documentation, laboratory workup confirming SIADH, exclusion of other causes, and follow-up after drug discontinuation.
Why This Research Matters
SIADH causing seizures is a potentially life-threatening complication not widely recognized with GLP-1 drugs. This case warns clinicians to monitor electrolytes when starting tirzepatide, even in low-risk patients.
What This Study Doesn't Tell Us
Single case. Cannot determine incidence of this complication. No rechallenge performed. Other unrecognized causes cannot be completely excluded.
Trust & Context
- Original Title:
- Tirzepatide-Induced Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) Presenting With Seizures.
- Published In:
- JCEM case reports, 3(12), luaf261 (2025)
- Authors:
- Shah, Islam, Sennik, Devesh, Veettil, Fahas Ali Vattiyam
- Database ID:
- RPEP-13526
Evidence Hierarchy
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-13526APA
Shah, Islam; Sennik, Devesh; Veettil, Fahas Ali Vattiyam. (2025). Tirzepatide-Induced Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) Presenting With Seizures.. JCEM case reports, 3(12), luaf261. https://doi.org/10.1210/jcemcr/luaf261
MLA
Shah, Islam, et al. "Tirzepatide-Induced Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) Presenting With Seizures.." JCEM case reports, 2025. https://doi.org/10.1210/jcemcr/luaf261
RethinkPeptides
RethinkPeptides Research Database. "Tirzepatide-Induced Syndrome of Inappropriate Antidiuretic H..." RPEP-13526. Retrieved from https://rethinkpeptides.com/research/shah-2025-tirzepatideinduced-syndrome-of-inappropriate
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.