Melanocortins for Both Male AND Female Sexual Dysfunction: PT-141 and Beyond
Melanocortin agonists (PT-141/bremelanotide, melanotan II) show efficacy for both male erectile dysfunction and female sexual arousal disorder through central MC3R/MC4R activation — the only drug class addressing desire in both sexes.
Quick Facts
What This Study Found
Melanocortin agonists (bremelanotide, melanotan II) treat sexual dysfunction in both sexes through central MC3R/MC4R activation: ED in men and HSDD/FSAD in women — the only drug class targeting desire/arousal centrally for both genders.
Key Numbers
How They Did This
review study.
Why This Research Matters
Relevant for pt-141, melanotan, sexual-health.
The Bigger Picture
Advances peptide research.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding Melanocortin agonists (bremelanotide, melanotan II) treat sexual dysfunction in both sexes through central MC3R/MC4R activation: ED in men and HSDD/FS
- Evidence Grade:
- moderate evidence.
- Study Age:
- Published in 2007.
- Original Title:
- Melanocortins in the treatment of male and female sexual dysfunction.
- Published In:
- Current topics in medicinal chemistry, 7(11), 1137-44 (2007)
- Authors:
- Shadiack, Annette M, Sharma, Shubh D, Earle, Dennis C(2), Spana, Carl, Hallam, Trevor J
- Database ID:
- RPEP-01288
Evidence Hierarchy
Summarizes existing research on a topic.
What do these levels mean? →Frequently Asked Questions
What was studied?
Melanocortins for Both Male AND Female Sexual Dysfunction: PT-141 and Beyond
What was found?
Melanocortin agonists (PT-141/bremelanotide, melanotan II) show efficacy for both male erectile dysfunction and female sexual arousal disorder through central MC3R/MC4R activation — the only drug class addressing desire in both sexes.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-01288APA
Shadiack, Annette M; Sharma, Shubh D; Earle, Dennis C; Spana, Carl; Hallam, Trevor J. (2007). Melanocortins in the treatment of male and female sexual dysfunction.. Current topics in medicinal chemistry, 7(11), 1137-44.
MLA
Shadiack, Annette M, et al. "Melanocortins in the treatment of male and female sexual dysfunction.." Current topics in medicinal chemistry, 2007.
RethinkPeptides
RethinkPeptides Research Database. "Melanocortins in the treatment of male and female sexual dys..." RPEP-01288. Retrieved from https://rethinkpeptides.com/research/shadiack-2007-melanocortins-in-the-treatment
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.