VPAC receptor positivity in comparison with mp-MRI in the diagnosis of prostate cancer: A preliminary study.
Quick Facts
What This Study Found
A urine test for VPAC receptors (which bind vasoactive intestinal peptide and PACAP) on cancer cells detected prostate cancer with 96% sensitivity and no false positives in a cohort of 61 patients with elevated PSA.
Key Numbers
61 patients. Median age 65.3, median PSA 9.56 ng/mL. 25 (41%) had PCa on biopsy. VPAC urine test: 96% sensitivity (24/25), 4% false negative (1/25), 0% false positive. By PIRADS: 3/16 PCa in PIRADS 2, 7/21 in PIRADS 3, 7/14 in PIRADS 4, 8/8 in PIRADS 5.
How They Did This
Prospective study of 61 men ≥40 years with LUTS and PSA >4 but <15 ng/mL. Voided urine VPAC receptor testing and mp-MRI performed. All underwent 12-core TRUS-guided biopsy as reference standard.
Why This Research Matters
Current prostate cancer screening with PSA has many false positives. A simple urine test with 96% sensitivity and zero false positives could reduce unnecessary biopsies.
What This Study Doesn't Tell Us
Small sample (61 patients, 25 cancers). Single center. PSA 4-15 range only. Biopsy as reference may miss some cancers. VPAC test specifics (assay details) limited in abstract.
Trust & Context
- Original Title:
- VPAC receptor positivity in comparison with mp-MRI in the diagnosis of prostate cancer: A preliminary study.
- Published In:
- BJUI compass, 6(4), e70006 (2025)
- Authors:
- Setya, Nishant, Ghagane, Shridhar C, Nerli, Rajendra B, Bokare, Ashwin, Thakur, Madhukar L, Gomella, Leonard
- Database ID:
- RPEP-13515
Evidence Hierarchy
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-13515APA
Setya, Nishant; Ghagane, Shridhar C; Nerli, Rajendra B; Bokare, Ashwin; Thakur, Madhukar L; Gomella, Leonard. (2025). VPAC receptor positivity in comparison with mp-MRI in the diagnosis of prostate cancer: A preliminary study.. BJUI compass, 6(4), e70006. https://doi.org/10.1002/bco2.70006
MLA
Setya, Nishant, et al. "VPAC receptor positivity in comparison with mp-MRI in the diagnosis of prostate cancer: A preliminary study.." BJUI compass, 2025. https://doi.org/10.1002/bco2.70006
RethinkPeptides
RethinkPeptides Research Database. "VPAC receptor positivity in comparison with mp-MRI in the di..." RPEP-13515. Retrieved from https://rethinkpeptides.com/research/setya-2025-vpac-receptor-positivity-in
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.