This record provides bibliographic details and links to the original research. An editorial study breakdown is not available.
What the researchers found
ACE-inhibitory peptides purified from green seaweed (Ulva rigida) and encapsulated in chitosan-coated nanoliposomes achieved 92% encapsulation efficiency and retained 37.5% of their blood pressure-lowering activity after encapsulation.
Why it matters
Natural peptides that lower blood pressure degrade quickly. Nanoliposome encapsulation could make them stable enough for use as functional food ingredients or supplements.
The numbers in context
Ulva rigida hydrolyzed with pepsin then trypsin. Peptides <3 kDa showed strongest ACE inhibition. Identified by mass spectrometry and in silico analysis. Nanoliposome encapsulation efficiency: 92.0 ± 4.5%. ACE-inhibitory activity retained: 37.5% after encapsulation.
How the study worked
Enzymatic hydrolysis of U. rigida protein, ultrafiltration by molecular weight, ion exchange chromatography, mass spectrometry and in silico peptide identification, nanoliposome formulation with chitosan coating, physical characterization (zeta potential, PDI, size, DSC, SEM, FT-IR), and ACE inhibition assay.
Who was studied
Ulva rigida green seaweed protein hydrolysates
What this study cannot tell us
In vitro only. Significant activity loss after encapsulation (62.5%). Oral bioavailability and in vivo antihypertensive effect not tested. Seaweed peptide yields may vary by batch.
Read the original research
Nanoliposomal Encapsulation and Purification of Angiotensin-Converting Enzyme Inhibitor Peptides from Ulva rigida.
ACS omega, 10(21), 21609-21620
Citation
Şensu, Eda; Koku, Harun; Demircan, Evren; Şişman, Sebahat; Gülseren, İbrahim; Karaduman, Tuğçe; Çakır, Bilal; Okudan, Emine Şükran; Duruksu, Gökhan; Özçelik, Beraat; Yücetepe, Aysun. (2025). Nanoliposomal Encapsulation and Purification of Angiotensin-Converting Enzyme Inhibitor Peptides from Ulva rigida.. ACS omega, 10(21), 21609-21620. https://doi.org/10.1021/acsomega.5c00780