Nanoliposomal Encapsulation and Purification of Angiotensin-Converting Enzyme Inhibitor Peptides from Ulva rigida.
Quick Facts
What This Study Found
ACE-inhibitory peptides purified from green seaweed (Ulva rigida) and encapsulated in chitosan-coated nanoliposomes achieved 92% encapsulation efficiency and retained 37.5% of their blood pressure-lowering activity after encapsulation.
Key Numbers
Ulva rigida hydrolyzed with pepsin then trypsin. Peptides <3 kDa showed strongest ACE inhibition. Identified by mass spectrometry and in silico analysis. Nanoliposome encapsulation efficiency: 92.0 ± 4.5%. ACE-inhibitory activity retained: 37.5% after encapsulation.
How They Did This
Enzymatic hydrolysis of U. rigida protein, ultrafiltration by molecular weight, ion exchange chromatography, mass spectrometry and in silico peptide identification, nanoliposome formulation with chitosan coating, physical characterization (zeta potential, PDI, size, DSC, SEM, FT-IR), and ACE inhibition assay.
Why This Research Matters
Natural peptides that lower blood pressure degrade quickly. Nanoliposome encapsulation could make them stable enough for use as functional food ingredients or supplements.
What This Study Doesn't Tell Us
In vitro only. Significant activity loss after encapsulation (62.5%). Oral bioavailability and in vivo antihypertensive effect not tested. Seaweed peptide yields may vary by batch.
Trust & Context
- Original Title:
- Nanoliposomal Encapsulation and Purification of Angiotensin-Converting Enzyme Inhibitor Peptides from Ulva rigida.
- Published In:
- ACS omega, 10(21), 21609-21620 (2025)
- Authors:
- Şensu, Eda, Koku, Harun, Demircan, Evren, Şişman, Sebahat, Gülseren, İbrahim, Karaduman, Tuğçe, Çakır, Bilal, Okudan, Emine Şükran, Duruksu, Gökhan, Özçelik, Beraat, Yücetepe, Aysun
- Database ID:
- RPEP-14681
Evidence Hierarchy
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Cite This Study
https://rethinkpeptides.com/research/RPEP-14681APA
Şensu, Eda; Koku, Harun; Demircan, Evren; Şişman, Sebahat; Gülseren, İbrahim; Karaduman, Tuğçe; Çakır, Bilal; Okudan, Emine Şükran; Duruksu, Gökhan; Özçelik, Beraat; Yücetepe, Aysun. (2025). Nanoliposomal Encapsulation and Purification of Angiotensin-Converting Enzyme Inhibitor Peptides from Ulva rigida.. ACS omega, 10(21), 21609-21620. https://doi.org/10.1021/acsomega.5c00780
MLA
Şensu, Eda, et al. "Nanoliposomal Encapsulation and Purification of Angiotensin-Converting Enzyme Inhibitor Peptides from Ulva rigida.." ACS omega, 2025. https://doi.org/10.1021/acsomega.5c00780
RethinkPeptides
RethinkPeptides Research Database. "Nanoliposomal Encapsulation and Purification of Angiotensin-..." RPEP-14681. Retrieved from https://rethinkpeptides.com/research/sensu-2025-nanoliposomal-encapsulation-and-purification
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.