This record provides bibliographic details and links to the original research. An editorial study breakdown is not available.
What the researchers found
As-CATH8 demonstrated potent in vitro activity against antibiotic-resistant bacteria, outperforming human LL-37.
Why it matters
With rising antibiotic resistance, new antimicrobial agents are urgently needed. As-CATH8 could provide an effective alternative for treating resistant infections.
How the study worked
The study involved genomic screening of four crocodylian species, synthesis of cathelicidins, and testing their antimicrobial activity in vitro and in a murine model.
What this study cannot tell us
The study primarily involves in vitro and animal models, which may not fully predict human responses.
Read the original research
Novel Alligator Cathelicidin As-CATH8 Demonstrates Anti-Infective Activity against Clinically Relevant and Crocodylian Bacterial Pathogens.
Antibiotics (Basel, Switzerland), 11(11)
Citation
Santana, Felix L; Estrada, Karel; Alford, Morgan A; Wu, Bing C; Dostert, Melanie; Pedraz, Lucas; Akhoundsadegh, Noushin; Kalsi, Pavneet; Haney, Evan F; Straus, Suzana K; Corzo, Gerardo; Hancock, Robert E W. (2022). Novel Alligator Cathelicidin As-CATH8 Demonstrates Anti-Infective Activity against Clinically Relevant and Crocodylian Bacterial Pathogens.. Antibiotics (Basel, Switzerland), 11(11). https://doi.org/10.3390/antibiotics11111603