Novel Alligator Cathelicidin As-CATH8 Demonstrates Anti-Infective Activity against Clinically Relevant and Crocodylian Bacterial Pathogens.
Quick Facts
What This Study Found
As-CATH8 demonstrated potent in vitro activity against antibiotic-resistant bacteria, outperforming human LL-37.
Key Numbers
How They Did This
The study involved genomic screening of four crocodylian species, synthesis of cathelicidins, and testing their antimicrobial activity in vitro and in a murine model.
Why This Research Matters
With rising antibiotic resistance, new antimicrobial agents are urgently needed. As-CATH8 could provide an effective alternative for treating resistant infections.
What This Study Doesn't Tell Us
The study primarily involves in vitro and animal models, which may not fully predict human responses.
Trust & Context
- Original Title:
- Novel Alligator Cathelicidin As-CATH8 Demonstrates Anti-Infective Activity against Clinically Relevant and Crocodylian Bacterial Pathogens.
- Published In:
- Antibiotics (Basel, Switzerland), 11(11) (2022)
- Authors:
- Santana, Felix L, Estrada, Karel, Alford, Morgan A, Wu, Bing C, Dostert, Melanie, Pedraz, Lucas, Akhoundsadegh, Noushin, Kalsi, Pavneet, Haney, Evan F, Straus, Suzana K, Corzo, Gerardo, Hancock, Robert E W
- Database ID:
- RPEP-06479
Evidence Hierarchy
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Cite This Study
https://rethinkpeptides.com/research/RPEP-06479APA
Santana, Felix L; Estrada, Karel; Alford, Morgan A; Wu, Bing C; Dostert, Melanie; Pedraz, Lucas; Akhoundsadegh, Noushin; Kalsi, Pavneet; Haney, Evan F; Straus, Suzana K; Corzo, Gerardo; Hancock, Robert E W. (2022). Novel Alligator Cathelicidin As-CATH8 Demonstrates Anti-Infective Activity against Clinically Relevant and Crocodylian Bacterial Pathogens.. Antibiotics (Basel, Switzerland), 11(11). https://doi.org/10.3390/antibiotics11111603
MLA
Santana, Felix L, et al. "Novel Alligator Cathelicidin As-CATH8 Demonstrates Anti-Infective Activity against Clinically Relevant and Crocodylian Bacterial Pathogens.." Antibiotics (Basel, 2022. https://doi.org/10.3390/antibiotics11111603
RethinkPeptides
RethinkPeptides Research Database. "Novel Alligator Cathelicidin As-CATH8 Demonstrates Anti-Infe..." RPEP-06479. Retrieved from https://rethinkpeptides.com/research/santana-2022-novel-alligator-cathelicidin-ascath8
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.