Central administration of galanin-like peptide (GALP) causes short-term orexigenic effects in broilers: Mediatory role of NPY1 and D1 receptors.
Quick Facts
What This Study Found
Galanin-like peptide (GALP) increased food intake in broiler chicks through NPY1 and D1 dopamine receptors. Blocking NPY1 suppressed the effect; blocking D1 enhanced it.
Key Numbers
GALP doses: 0.5, 1, 2 mcg; 1 and 2 mcg increased food intake (p<0.05); NPY1 antagonist (BIBO-3304) blocked effect; D1 antagonist (SCH39166) enhanced effect; NPY2, NPY5, D2 antagonists had no effect
How They Did This
Central (intracerebroventricular) peptide and antagonist administration in broiler chicks. Cumulative food intake measured over 2 hours. Behavioral observations for 30 minutes. Six experiments testing different receptor antagonist combinations.
Why This Research Matters
Understanding how appetite-regulating peptides interact with dopamine and NPY systems in poultry could improve feed efficiency and reveal conserved mechanisms relevant to human appetite research.
What This Study Doesn't Tell Us
Poultry model; brain peptide pathways may differ from mammals. Acute single-injection protocol. Central administration bypasses normal delivery. Small sample sizes typical of poultry neuroscience.
Trust & Context
- Original Title:
- Central administration of galanin-like peptide (GALP) causes short-term orexigenic effects in broilers: Mediatory role of NPY1 and D1 receptors.
- Published In:
- Neuroscience letters, 844, 138042 (2025)
- Database ID:
- RPEP-13403
Evidence Hierarchy
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Cite This Study
https://rethinkpeptides.com/research/RPEP-13403APA
Sanadgol, Elham; Zendehdel, Morteza; Vazir, Bita; Rassouli, Ali; Haghbinnazarpak, Hadi. (2025). Central administration of galanin-like peptide (GALP) causes short-term orexigenic effects in broilers: Mediatory role of NPY1 and D1 receptors.. Neuroscience letters, 844, 138042. https://doi.org/10.1016/j.neulet.2024.138042
MLA
Sanadgol, Elham, et al. "Central administration of galanin-like peptide (GALP) causes short-term orexigenic effects in broilers: Mediatory role of NPY1 and D1 receptors.." Neuroscience letters, 2025. https://doi.org/10.1016/j.neulet.2024.138042
RethinkPeptides
RethinkPeptides Research Database. "Central administration of galanin-like peptide (GALP) causes..." RPEP-13403. Retrieved from https://rethinkpeptides.com/research/sanadgol-2025-central-administration-of-galaninlike
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.