This record provides bibliographic details and links to the original research. An editorial study breakdown is not available.
What the researchers found
Galanin-like peptide (GALP) increased food intake in broiler chicks through NPY1 and D1 dopamine receptors. Blocking NPY1 suppressed the effect; blocking D1 enhanced it.
Why it matters
Understanding how appetite-regulating peptides interact with dopamine and NPY systems in poultry could improve feed efficiency and reveal conserved mechanisms relevant to human appetite research.
The numbers in context
GALP doses: 0.5, 1, 2 mcg; 1 and 2 mcg increased food intake (p<0.05); NPY1 antagonist (BIBO-3304) blocked effect; D1 antagonist (SCH39166) enhanced effect; NPY2, NPY5, D2 antagonists had no effect
How the study worked
Central (intracerebroventricular) peptide and antagonist administration in broiler chicks. Cumulative food intake measured over 2 hours. Behavioral observations for 30 minutes. Six experiments testing different receptor antagonist combinations.
Who was studied
Broiler chicks receiving central administration of GALP and receptor antagonists
What this study cannot tell us
Poultry model; brain peptide pathways may differ from mammals. Acute single-injection protocol. Central administration bypasses normal delivery. Small sample sizes typical of poultry neuroscience.
Read the original research
Central administration of galanin-like peptide (GALP) causes short-term orexigenic effects in broilers: Mediatory role of NPY1 and D1 receptors.
Neuroscience letters, 844, 138042
Citation
Sanadgol, Elham; Zendehdel, Morteza; Vazir, Bita; Rassouli, Ali; Haghbinnazarpak, Hadi. (2025). Central administration of galanin-like peptide (GALP) causes short-term orexigenic effects in broilers: Mediatory role of NPY1 and D1 receptors.. Neuroscience letters, 844, 138042. https://doi.org/10.1016/j.neulet.2024.138042