Novel GHS-R1A antagonists reduced food intake and altered hypothalamic neuron firing patterns in rats, validating ghrelin receptor blockade as an appetite-suppressing mechanism for obesity drug development.
Key findingNovel GHS-R1A antagonists reduced food intake and altered hypothalamic neuron firing patterns in rats, validating ghrelin receptor blockade as an appe
What the researchers found
Novel GHS-R1A antagonists reduced food intake and altered hypothalamic neuron firing patterns in rats, validating ghrelin receptor blockade as an appetite-suppressing mechanism for obesity drug development.
Why it matters
Relevant for peptide research.
How the study worked
research study.
What this study cannot tell us
See abstract.
How to read the evidence
emerging evidence.
When this study was published
Published in 2009.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
Common questions
What was studied?
What was found?
Read the original research
Anorexigenic and electrophysiological actions of novel ghrelin receptor (GHS-R1A) antagonists in rats.
European journal of pharmacology, 612(1-3), 167-73
Citation
Salomé, Nicolas; Haage, David; Perrissoud, Daniel; Moulin, Aline; Demange, Luc; Egecioglu, Emil; Fehrentz, Jean-Alain; Martinez, Jean; Dickson, Suzanne L. (2009). Anorexigenic and electrophysiological actions of novel ghrelin receptor (GHS-R1A) antagonists in rats.. European journal of pharmacology, 612(1-3), 167-73. https://doi.org/10.1016/j.ejphar.2009.03.066