This record provides bibliographic details and links to the original research. An editorial study breakdown is not available.
What the researchers found
A GLP-1 receptor-targeted PET scan (18F-exendin-4) found an occult insulinoma that CT, MRI, endoscopic ultrasound, and calcium stimulation testing all missed, enabling curative surgery.
Why it matters
Insulinomas are hard to find with standard imaging. GLP-1 receptor PET offers a new non-invasive option that may locate tumors when everything else fails.
The numbers in context
1 patient; age 67 at onset, 73 at surgery; 6 years on diazoxide; negative on CT, MRI, EUS, and SACST; positive on 18F-exendin-4 PET/CT; complete remission post-surgery
How the study worked
Single case report describing diagnostic workup including CT, MRI, EUS, SACST, and 18F-exendin-4 PET/CT, followed by surgical resection and histopathology.
Who was studied
73-year-old woman with hyperinsulinemic hypoglycemia and occult insulinoma
What this study cannot tell us
Single case. Availability of 18F-exendin-4 PET/CT is very limited. Cost-effectiveness unknown. Cannot determine sensitivity/specificity from one case.
Read the original research
Case Report: A case of occult insulinoma localized by [18F] FB (ePEG12)12-exendin-4 positron emission tomography with negative findings of selective arterial calcium stimulation test.
Frontiers in endocrinology, 16, 1556813
Citation
Sakaki, Kentaro; Murakami, Takaaki; Fujimoto, Hiroyuki; Shimizu, Yoichi; Miyake, Kanae Kawai; Otani, Daisuke; Otsuki, Shinya; Shimizu, Hironori; Nagai, Kazuyuki; Nomura, Takumi; Yabe, Daisuke; Nakamoto, Yuji; Inagaki, Nobuya. (2025). Case Report: A case of occult insulinoma localized by [18F] FB (ePEG12)12-exendin-4 positron emission tomography with negative findings of selective arterial calcium stimulation test.. Frontiers in endocrinology, 16, 1556813. https://doi.org/10.3389/fendo.2025.1556813