Case Report: A case of occult insulinoma localized by [18F] FB (ePEG12)12-exendin-4 positron emission tomography with negative findings of selective arterial calcium stimulation test.
Quick Facts
What This Study Found
A GLP-1 receptor-targeted PET scan (18F-exendin-4) found an occult insulinoma that CT, MRI, endoscopic ultrasound, and calcium stimulation testing all missed, enabling curative surgery.
Key Numbers
1 patient; age 67 at onset, 73 at surgery; 6 years on diazoxide; negative on CT, MRI, EUS, and SACST; positive on 18F-exendin-4 PET/CT; complete remission post-surgery
How They Did This
Single case report describing diagnostic workup including CT, MRI, EUS, SACST, and 18F-exendin-4 PET/CT, followed by surgical resection and histopathology.
Why This Research Matters
Insulinomas are hard to find with standard imaging. GLP-1 receptor PET offers a new non-invasive option that may locate tumors when everything else fails.
What This Study Doesn't Tell Us
Single case. Availability of 18F-exendin-4 PET/CT is very limited. Cost-effectiveness unknown. Cannot determine sensitivity/specificity from one case.
Trust & Context
- Original Title:
- Case Report: A case of occult insulinoma localized by [18F] FB (ePEG12)12-exendin-4 positron emission tomography with negative findings of selective arterial calcium stimulation test.
- Published In:
- Frontiers in endocrinology, 16, 1556813 (2025)
- Authors:
- Sakaki, Kentaro, Murakami, Takaaki(3), Fujimoto, Hiroyuki, Shimizu, Yoichi, Miyake, Kanae Kawai, Otani, Daisuke, Otsuki, Shinya, Shimizu, Hironori, Nagai, Kazuyuki, Nomura, Takumi, Yabe, Daisuke, Nakamoto, Yuji, Inagaki, Nobuya
- Database ID:
- RPEP-13379
Evidence Hierarchy
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-13379APA
Sakaki, Kentaro; Murakami, Takaaki; Fujimoto, Hiroyuki; Shimizu, Yoichi; Miyake, Kanae Kawai; Otani, Daisuke; Otsuki, Shinya; Shimizu, Hironori; Nagai, Kazuyuki; Nomura, Takumi; Yabe, Daisuke; Nakamoto, Yuji; Inagaki, Nobuya. (2025). Case Report: A case of occult insulinoma localized by [18F] FB (ePEG12)12-exendin-4 positron emission tomography with negative findings of selective arterial calcium stimulation test.. Frontiers in endocrinology, 16, 1556813. https://doi.org/10.3389/fendo.2025.1556813
MLA
Sakaki, Kentaro, et al. "Case Report: A case of occult insulinoma localized by [18F] FB (ePEG12)12-exendin-4 positron emission tomography with negative findings of selective arterial calcium stimulation test.." Frontiers in endocrinology, 2025. https://doi.org/10.3389/fendo.2025.1556813
RethinkPeptides
RethinkPeptides Research Database. "Case Report: A case of occult insulinoma localized by [18F] ..." RPEP-13379. Retrieved from https://rethinkpeptides.com/research/sakaki-2025-case-report-a-case
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.