Blood Pressure-Lowering Peptides From Milk: Casein and Whey-Derived ACE Inhibitors

Multiple antihypertensive peptides derived from bovine casein and whey proteins inhibit ACE and lower blood pressure, with some (IPP, VPP) showing clinical benefit — functional food peptides for cardiovascular health.

Saito, Tadao·Advances in experimental medicine and biology·2008·Moderate EvidenceReview
RPEP-01415ReviewModerate Evidence2008RETHINKTHC RESEARCH DATABASErethinkthc.com/research

Quick Facts

Study Type
Review
Evidence
Moderate Evidence
Sample
Not reported

What This Study Found

Casein-derived (IPP, VPP, alpha-casein fragments) and whey-derived (alpha-lactalbumin, beta-lactoglobulin peptides) ACE-inhibitory peptides lower blood pressure in animal and human studies — the most validated functional food peptides for cardiovascular health.

Key Numbers

How They Did This

review study.

Why This Research Matters

Relevant for bioactive-food-peptides, cardiovascular.

The Bigger Picture

Advances peptide research.

What This Study Doesn't Tell Us

See abstract.

Questions This Raises

  • ?Further research needed.
  • ?Clinical translation to evaluate.

Trust & Context

Key Stat:
Key finding Casein-derived (IPP, VPP, alpha-casein fragments) and whey-derived (alpha-lactalbumin, beta-lactoglobulin peptides) ACE-inhibitory peptides lower bloo
Evidence Grade:
moderate evidence.
Study Age:
Published in 2008.
Original Title:
Antihypertensive peptides derived from bovine casein and whey proteins.
Published In:
Advances in experimental medicine and biology, 606, 295-317 (2008)
Authors:
Saito, Tadao
Database ID:
RPEP-01415

Evidence Hierarchy

Meta-Analysis / Systematic Review
Randomized Controlled Trial
Cohort / Case-Control
Cross-Sectional / ObservationalSnapshot without intervening
This study
Case Report / Animal Study

Summarizes existing research on a topic.

What do these levels mean? →

Frequently Asked Questions

What was studied?

Blood Pressure-Lowering Peptides From Milk: Casein and Whey-Derived ACE Inhibitors

What was found?

Multiple antihypertensive peptides derived from bovine casein and whey proteins inhibit ACE and lower blood pressure, with some (IPP, VPP) showing clinical benefit — functional food peptides for cardiovascular health.

Read More on RethinkPeptides

Cite This Study

RPEP-01415·https://rethinkpeptides.com/research/RPEP-01415

APA

Saito, Tadao. (2008). Antihypertensive peptides derived from bovine casein and whey proteins.. Advances in experimental medicine and biology, 606, 295-317. https://doi.org/10.1007/978-0-387-74087-4_12

MLA

Saito, Tadao. "Antihypertensive peptides derived from bovine casein and whey proteins.." Advances in experimental medicine and biology, 2008. https://doi.org/10.1007/978-0-387-74087-4_12

RethinkPeptides

RethinkPeptides Research Database. "Antihypertensive peptides derived from bovine casein and whe..." RPEP-01415. Retrieved from https://rethinkpeptides.com/research/saito-2008-antihypertensive-peptides-derived-from

Access the Original Study

Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.

This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.