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Study breakdown

Blood Pressure-Lowering Peptides From Milk: Casein and Whey-Derived ACE Inhibitors

ReviewModerate evidence
The takeaway

Multiple antihypertensive peptides derived from bovine casein and whey proteins inhibit ACE and lower blood pressure, with some (IPP, VPP) showing clinical benefit — functional food peptides for cardiovascular health.

Key finding

Casein-derived (IPP, VPP, alpha-casein fragments) and whey-derived (alpha-lactalbumin, beta-lactoglobulin peptides) ACE-inhibitory peptides lower bloo

What the researchers found

Casein-derived (IPP, VPP, alpha-casein fragments) and whey-derived (alpha-lactalbumin, beta-lactoglobulin peptides) ACE-inhibitory peptides lower blood pressure in animal and human studies — the most validated functional food peptides for cardiovascular health.

Why it matters

Relevant for bioactive-food-peptides, cardiovascular.

How the study worked

review study.

What this study cannot tell us

See abstract.

How to read the evidence

moderate evidence.

When this study was published

Published in 2008.

The bigger picture

Advances peptide research.

Questions still open

  • Further research needed.
  • Clinical translation to evaluate.

Common questions

What was studied?
Blood Pressure-Lowering Peptides From Milk: Casein and Whey-Derived ACE Inhibitors
What was found?
Multiple antihypertensive peptides derived from bovine casein and whey proteins inhibit ACE and lower blood pressure, with some (IPP, VPP) showing clinical benefit — functional food peptides for cardiovascular health.

Read the original research

Antihypertensive peptides derived from bovine casein and whey proteins.

Advances in experimental medicine and biology, 606, 295-317

Citation

Saito, Tadao. (2008). Antihypertensive peptides derived from bovine casein and whey proteins.. Advances in experimental medicine and biology, 606, 295-317. https://doi.org/10.1007/978-0-387-74087-4_12