VIP gene modulated pulmonary vascular remodeling and inflammation, with VIP-deficient mice developing pulmonary hypertension — establishing VIP as a key protective factor for lung vascular health.
Key findingVIP gene expression was essential for normal pulmonary vascular regulation, with VIP knockout mice developing spontaneous pulmonary hypertension and v
What the researchers found
VIP gene expression was essential for normal pulmonary vascular regulation, with VIP knockout mice developing spontaneous pulmonary hypertension and vascular remodeling — establishing VIP as an endogenous protective factor against pulmonary vascular disease.
Why it matters
Relevant for neuropeptides, respiratory, inflammation.
How the study worked
animal-study study.
What this study cannot tell us
See abstract.
How to read the evidence
preliminary evidence.
When this study was published
Published in 2008.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
The vasoactive intestinal peptide gene is a key modulator of pulmonary vascular remodeling and inflammation.
Annals of the New York Academy of Sciences, 1144, 148-53
Citation
Said, Sami I. (2008). The vasoactive intestinal peptide gene is a key modulator of pulmonary vascular remodeling and inflammation.. Annals of the New York Academy of Sciences, 1144, 148-53. https://doi.org/10.1196/annals.1418.014