VIP Gene Is Key to Lung Blood Vessel Remodeling and Pulmonary Inflammation
VIP gene modulated pulmonary vascular remodeling and inflammation, with VIP-deficient mice developing pulmonary hypertension — establishing VIP as a key protective factor for lung vascular health.
Quick Facts
What This Study Found
VIP gene expression was essential for normal pulmonary vascular regulation, with VIP knockout mice developing spontaneous pulmonary hypertension and vascular remodeling — establishing VIP as an endogenous protective factor against pulmonary vascular disease.
Key Numbers
How They Did This
animal-study study.
Why This Research Matters
Relevant for neuropeptides, respiratory, inflammation.
The Bigger Picture
Advances peptide research.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding VIP gene expression was essential for normal pulmonary vascular regulation, with VIP knockout mice developing spontaneous pulmonary hypertension and v
- Evidence Grade:
- preliminary evidence.
- Study Age:
- Published in 2008.
- Original Title:
- The vasoactive intestinal peptide gene is a key modulator of pulmonary vascular remodeling and inflammation.
- Published In:
- Annals of the New York Academy of Sciences, 1144, 148-53 (2008)
- Authors:
- Said, Sami I
- Database ID:
- RPEP-01414
Evidence Hierarchy
Tests effects in animals (usually mice or rats), not humans.
What do these levels mean? →Frequently Asked Questions
What was studied?
VIP Gene Is Key to Lung Blood Vessel Remodeling and Pulmonary Inflammation
What was found?
VIP gene modulated pulmonary vascular remodeling and inflammation, with VIP-deficient mice developing pulmonary hypertension — establishing VIP as a key protective factor for lung vascular health.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-01414APA
Said, Sami I. (2008). The vasoactive intestinal peptide gene is a key modulator of pulmonary vascular remodeling and inflammation.. Annals of the New York Academy of Sciences, 1144, 148-53. https://doi.org/10.1196/annals.1418.014
MLA
Said, Sami I. "The vasoactive intestinal peptide gene is a key modulator of pulmonary vascular remodeling and inflammation.." Annals of the New York Academy of Sciences, 2008. https://doi.org/10.1196/annals.1418.014
RethinkPeptides
RethinkPeptides Research Database. "The vasoactive intestinal peptide gene is a key modulator of..." RPEP-01414. Retrieved from https://rethinkpeptides.com/research/said-2008-the-vasoactive-intestinal-peptide
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.