Rational design of cyclic peptides, with an emphasis on bicyclic peptides.
Quick Facts
What This Study Found
Cyclic and bicyclic peptides offer better stability and bioavailability than linear peptides while keeping the ability to block protein-protein interactions that small molecules cannot reach.
Key Numbers
N/A (review of design methodologies)
How They Did This
Narrative review of recent literature on macrocyclic and bicyclic peptide design, including computational, structure-guided, and phage display approaches.
Why This Research Matters
Protein-protein interactions drive many diseases but are hard to drug. Cyclic peptides fill a gap between small molecules and large biologics as a new class of therapeutics.
What This Study Doesn't Tell Us
Narrative review without systematic methodology. Focuses on design principles rather than clinical outcomes. May not cover all recent developments equally.
Trust & Context
- Original Title:
- Rational design of cyclic peptides, with an emphasis on bicyclic peptides.
- Published In:
- Current opinion in structural biology, 92, 103025 (2025)
- Database ID:
- RPEP-13321
Evidence Hierarchy
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-13321APA
Rowland, Catherine E; Bezerra, Gustavo Arruda; Skynner, Michael J. (2025). Rational design of cyclic peptides, with an emphasis on bicyclic peptides.. Current opinion in structural biology, 92, 103025. https://doi.org/10.1016/j.sbi.2025.103025
MLA
Rowland, Catherine E, et al. "Rational design of cyclic peptides, with an emphasis on bicyclic peptides.." Current opinion in structural biology, 2025. https://doi.org/10.1016/j.sbi.2025.103025
RethinkPeptides
RethinkPeptides Research Database. "Rational design of cyclic peptides, with an emphasis on bicy..." RPEP-13321. Retrieved from https://rethinkpeptides.com/research/rowland-2025-rational-design-of-cyclic
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.