Substance P and neurokinin 1 receptor boost the pathogenicity of granulocyte-macrophage colony-stimulating factor-producing T helper cells in dry eye disease.
Quick Facts
What This Study Found
Substance P amplified the pathogenicity of GM-CSF-producing T helper cells in dry eye disease through the NK1R receptor. Blocking NK1R reduced disease severity in a mouse model.
Key Numbers
Substance P increased GM-CSF expression in ThGM cells. NK1R-expressing ThGM transfer significantly exacerbated DED. NK1R-knockdown ThGM weakly aggravated DED. NK2R knockdown had no effect.
How They Did This
Murine dry eye disease model. Characterized NK1R and NK2R expression on ThGM and Th1 cells. Substance P and NKA stimulation assays. Adoptive transfer of NK1R-expressing vs. NK1R-knockdown ThGM cells.
Why This Research Matters
Dry eye disease is an inflammatory condition where neuropeptides and immune cells interact. Identifying the substance P-NK1R axis as a driver opens a new therapeutic target for this common condition.
What This Study Doesn't Tell Us
Mouse model only. DED in humans may involve different immune mechanisms. Adoptive transfer experiments are artificial. NK1R antagonists not tested therapeutically.
Trust & Context
- Original Title:
- Substance P and neurokinin 1 receptor boost the pathogenicity of granulocyte-macrophage colony-stimulating factor-producing T helper cells in dry eye disease.
- Published In:
- Scandinavian journal of immunology, 101(1), e13434 (2025)
- Authors:
- Rong, Hua, Yang, Hai, Liu, Qingqing, Zhang, Hui, Wang, Shaolin
- Database ID:
- RPEP-13301
Evidence Hierarchy
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Cite This Study
https://rethinkpeptides.com/research/RPEP-13301APA
Rong, Hua; Yang, Hai; Liu, Qingqing; Zhang, Hui; Wang, Shaolin. (2025). Substance P and neurokinin 1 receptor boost the pathogenicity of granulocyte-macrophage colony-stimulating factor-producing T helper cells in dry eye disease.. Scandinavian journal of immunology, 101(1), e13434. https://doi.org/10.1111/sji.13434
MLA
Rong, Hua, et al. "Substance P and neurokinin 1 receptor boost the pathogenicity of granulocyte-macrophage colony-stimulating factor-producing T helper cells in dry eye disease.." Scandinavian journal of immunology, 2025. https://doi.org/10.1111/sji.13434
RethinkPeptides
RethinkPeptides Research Database. "Substance P and neurokinin 1 receptor boost the pathogenicit..." RPEP-13301. Retrieved from https://rethinkpeptides.com/research/rong-2025-substance-p-and-neurokinin
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.