How Each Endogenous Opioid Peptide Contributes to the Heart's Natural Ischemic Protection
Endogenous enkephalins, endorphins, and dynorphins each contributed differently to myocardial ischemic tolerance, with delta-opioid (enkephalin) and kappa-opioid (dynorphin) pathways showing the greatest cardioprotective roles.
Quick Facts
What This Study Found
Selective opioid receptor and peptide antibody blocking revealed delta-opioid (enkephalin) and kappa-opioid (dynorphin) systems as the primary contributors to myocardial ischemic tolerance, with quantified relative contributions of each endogenous opioid family.
Key Numbers
How They Did This
animal-study study on opioid-peptides, cardiovascular.
Why This Research Matters
Relevant for opioid-peptides, cardiovascular, receptor-signaling.
The Bigger Picture
Advances peptide therapeutics research.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding Selective opioid receptor and peptide antibody blocking revealed delta-opioid (enkephalin) and kappa-opioid (dynorphin) systems as the primary contrib
- Evidence Grade:
- preliminary evidence.
- Study Age:
- Published in 2004.
- Original Title:
- Relative contribution of endogenous opioids to myocardial ischemic tolerance.
- Published In:
- The Journal of surgical research, 118(1), 32-7 (2004)
- Authors:
- Romano, Matthew A, Seymour, Elisabeth M, Berry, Jennifer A, McNish, Robert A, Bolling, Steven F
- Database ID:
- RPEP-00968
Evidence Hierarchy
Tests effects in animals (usually mice or rats), not humans.
What do these levels mean? →Frequently Asked Questions
What was studied?
How Each Endogenous Opioid Peptide Contributes to the Heart's Natural Ischemic Protection
What was found?
Endogenous enkephalins, endorphins, and dynorphins each contributed differently to myocardial ischemic tolerance, with delta-opioid (enkephalin) and kappa-opioid (dynorphin) pathways showing the greatest cardioprotective roles.
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Cite This Study
https://rethinkpeptides.com/research/RPEP-00968APA
Romano, Matthew A; Seymour, Elisabeth M; Berry, Jennifer A; McNish, Robert A; Bolling, Steven F. (2004). Relative contribution of endogenous opioids to myocardial ischemic tolerance.. The Journal of surgical research, 118(1), 32-7.
MLA
Romano, Matthew A, et al. "Relative contribution of endogenous opioids to myocardial ischemic tolerance.." The Journal of surgical research, 2004.
RethinkPeptides
RethinkPeptides Research Database. "Relative contribution of endogenous opioids to myocardial is..." RPEP-00968. Retrieved from https://rethinkpeptides.com/research/romano-2004-relative-contribution-of-endogenous
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.