Endogenous enkephalins, endorphins, and dynorphins each contributed differently to myocardial ischemic tolerance, with delta-opioid (enkephalin) and kappa-opioid (dynorphin) pathways showing the greatest cardioprotective roles.
Key findingSelective opioid receptor and peptide antibody blocking revealed delta-opioid (enkephalin) and kappa-opioid (dynorphin) systems as the primary contrib
What the researchers found
Selective opioid receptor and peptide antibody blocking revealed delta-opioid (enkephalin) and kappa-opioid (dynorphin) systems as the primary contributors to myocardial ischemic tolerance, with quantified relative contributions of each endogenous opioid family.
Why it matters
Relevant for opioid-peptides, cardiovascular, receptor-signaling.
How the study worked
animal-study study on opioid-peptides, cardiovascular.
What this study cannot tell us
See abstract.
How to read the evidence
preliminary evidence.
When this study was published
Published in 2004.
The bigger picture
Advances peptide therapeutics research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Relative contribution of endogenous opioids to myocardial ischemic tolerance.
The Journal of surgical research, 118(1), 32-7
Citation
Romano, Matthew A; Seymour, Elisabeth M; Berry, Jennifer A; McNish, Robert A; Bolling, Steven F. (2004). Relative contribution of endogenous opioids to myocardial ischemic tolerance.. The Journal of surgical research, 118(1), 32-7.