Neutrophil-released opioid peptides produced pain relief in non-inflamed tissue when triggered by hypertonic stimulation, demonstrating immune-derived opioid analgesia extends beyond inflammatory contexts — broader peripheral pain control.
Key findingNeutrophil-released opioid peptides produced pain relief in non-inflamed tissue when triggered by hypertonic stimulation, demonstrating immune-derived
What the researchers found
Neutrophil-released opioid peptides produced pain relief in non-inflamed tissue when triggered by hypertonic stimulation, demonstrating immune-derived opioid analgesia extends beyond inflammatory contexts — broader peripheral pain control.
Why it matters
Relevant for peptide research.
How the study worked
research study.
What this study cannot tell us
See abstract.
How to read the evidence
emerging evidence.
When this study was published
Published in 2009.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
Common questions
What was studied?
What was found?
Read the original research
Antinociception by neutrophil-derived opioid peptides in noninflamed tissue--role of hypertonicity and the perineurium.
Brain, behavior, and immunity, 23(4), 548-57
Citation
Rittner, H L; Hackel, D; Yamdeu, R-S; Mousa, S A; Stein, C; Schäfer, M; Brack, A. (2009). Antinociception by neutrophil-derived opioid peptides in noninflamed tissue--role of hypertonicity and the perineurium.. Brain, behavior, and immunity, 23(4), 548-57. https://doi.org/10.1016/j.bbi.2009.02.007