Neutrophil-Derived Opioid Peptides Reduce Pain Even Without Inflammation
Neutrophil-released opioid peptides produced pain relief in non-inflamed tissue when triggered by hypertonic stimulation, demonstrating immune-derived opioid analgesia extends beyond inflammatory contexts — broader peripheral pain control.
Quick Facts
What This Study Found
Neutrophil-released opioid peptides produced pain relief in non-inflamed tissue when triggered by hypertonic stimulation, demonstrating immune-derived opioid analgesia extends beyond inflammatory contexts — broader peripheral pain control.
Key Numbers
How They Did This
research study.
Why This Research Matters
Relevant for peptide research.
The Bigger Picture
Advances peptide research.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
Trust & Context
- Key Stat:
- Key finding Neutrophil-released opioid peptides produced pain relief in non-inflamed tissue when triggered by hypertonic stimulation, demonstrating immune-derived
- Evidence Grade:
- emerging evidence.
- Study Age:
- Published in 2009.
- Original Title:
- Antinociception by neutrophil-derived opioid peptides in noninflamed tissue--role of hypertonicity and the perineurium.
- Published In:
- Brain, behavior, and immunity, 23(4), 548-57 (2009)
- Authors:
- Rittner, H L, Hackel, D, Yamdeu, R-S, Mousa, S A, Stein, C, Schäfer, M, Brack, A
- Database ID:
- RPEP-01540
Evidence Hierarchy
Frequently Asked Questions
What was studied?
Neutrophil-Derived Opioid Peptides Reduce Pain Even Without Inflammation
What was found?
Neutrophil-released opioid peptides produced pain relief in non-inflamed tissue when triggered by hypertonic stimulation, demonstrating immune-derived opioid analgesia extends beyond inflammatory contexts — broader peripheral pain control.
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Cite This Study
https://rethinkpeptides.com/research/RPEP-01540APA
Rittner, H L; Hackel, D; Yamdeu, R-S; Mousa, S A; Stein, C; Schäfer, M; Brack, A. (2009). Antinociception by neutrophil-derived opioid peptides in noninflamed tissue--role of hypertonicity and the perineurium.. Brain, behavior, and immunity, 23(4), 548-57. https://doi.org/10.1016/j.bbi.2009.02.007
MLA
Rittner, H L, et al. "Antinociception by neutrophil-derived opioid peptides in noninflamed tissue--role of hypertonicity and the perineurium.." Brain, 2009. https://doi.org/10.1016/j.bbi.2009.02.007
RethinkPeptides
RethinkPeptides Research Database. "Antinociception by neutrophil-derived opioid peptides in non..." RPEP-01540. Retrieved from https://rethinkpeptides.com/research/rittner-2009-antinociception-by-neutrophilderived-opioid
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.