Testosterone inhibited the GH response to GH secretagogues in both rats and dogs, revealing an androgen-GH axis interaction that explains why testosterone supplementation doesn't synergize with GHRP for GH release.
Key findingTestosterone administration inhibited GH secretagogue-stimulated GH release in both rats and dogs, likely through enhanced somatostatin tone, explaini
What the researchers found
Testosterone administration inhibited GH secretagogue-stimulated GH release in both rats and dogs, likely through enhanced somatostatin tone, explaining the lack of synergy between testosterone and GH peptides and informing combination therapy design.
Why it matters
Relevant for ghrp, hormone-optimization.
How the study worked
animal-study study on ghrp, hormone-optimization.
What this study cannot tell us
See abstract.
How to read the evidence
moderate evidence.
When this study was published
Published in 2006.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Testosterone inhibition of growth hormone release stimulated by a growth hormone secretagogue: studies in the rat and dog.
Neuroendocrinology, 84(2), 115-22
Citation
Rigamonti, Antonello E; Cella, Silvano G; Giordani, Claudio; Bonomo, Sara M; Giunta, Marialuisa; Sartorio, Alessandro; Muller, Eugenio. (2006). Testosterone inhibition of growth hormone release stimulated by a growth hormone secretagogue: studies in the rat and dog.. Neuroendocrinology, 84(2), 115-22.