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GHRH Antagonists Shrink Enlarged Prostates in Rats: A New Approach to BPH Treatment

evidence
The takeaway

GHRH antagonists reduced prostate size in experimental benign prostatic hyperplasia, with effects comparable to finasteride — offering a novel GH-axis-based approach to treating enlarged prostate without affecting testosterone.

Key finding

GHRH antagonists reduced prostate size in experimental benign prostatic hyperplasia, with effects comparable to finasteride — offering a novel GH-axis

What the researchers found

GHRH antagonists reduced prostate size in experimental benign prostatic hyperplasia, with effects comparable to finasteride — offering a novel GH-axis-based approach to treating enlarged prostate without affecting testosterone.

Why it matters

Relevant for peptide research.

How the study worked

research study.

What this study cannot tell us

See abstract.

How to read the evidence

emerging evidence.

When this study was published

Published in 2011.

The bigger picture

Advances peptide research.

Questions still open

  • Further research needed.

Common questions

What was studied?
GHRH Antagonists Shrink Enlarged Prostates in Rats: A New Approach to BPH Treatment
What was found?
GHRH antagonists reduced prostate size in experimental benign prostatic hyperplasia, with effects comparable to finasteride — offering a novel GH-axis-based approach to treating enlarged prostate without affecting testosterone.

Read the original research

Antagonists of growth hormone-releasing hormone (GHRH) reduce prostate size in experimental benign prostatic hyperplasia.

Proceedings of the National Academy of Sciences of the United States of America, 108(9), 3755-60

Citation

Rick, Ferenc G; Schally, Andrew V; Block, Norman L; Nadji, Mehrdad; Szepeshazi, Karoly; Zarandi, Marta; Vidaurre, Irving; Perez, Roberto; Halmos, Gabor; Szalontay, Luca. (2011). Antagonists of growth hormone-releasing hormone (GHRH) reduce prostate size in experimental benign prostatic hyperplasia.. Proceedings of the National Academy of Sciences of the United States of America, 108(9), 3755-60. https://doi.org/10.1073/pnas.1018086108