Weight Reduction with GLP-1 Agonists and Paths for Discontinuation While Maintaining Weight Loss.
Quick Facts
What This Study Found
GLP-1 agonists reduce body weight by 15-25% over about one year, but most patients regain weight after stopping. The review discusses strategies for safe discontinuation while maintaining weight loss.
Key Numbers
40% of adults worldwide are overweight, 13% are obese. GLP-1 drugs reduce body weight by 15-25% after about 1 year. Boxed warning for medullary thyroid carcinoma and MEN2 history.
How They Did This
Narrative review of GLP-1 agonist mechanisms, efficacy, adverse effects, and discontinuation strategies for obesity treatment.
Why This Research Matters
Weight regain after stopping GLP-1 drugs is one of the biggest challenges in obesity treatment. Finding ways to taper off these medications without losing progress is critical for long-term success.
What This Study Doesn't Tell Us
Review article without original data. No proven discontinuation protocols exist. Long-term data on weight maintenance after stopping are limited. Newer agents have very short track records.
Trust & Context
- Original Title:
- Weight Reduction with GLP-1 Agonists and Paths for Discontinuation While Maintaining Weight Loss.
- Published In:
- Biomolecules, 15(3) (2025)
- Authors:
- Reiss, Allison B, Gulkarov, Shelly, Lau, Raymond, Klek, Stanislaw P, Srivastava, Ankita, Renna, Heather A, De Leon, Joshua
- Database ID:
- RPEP-13234
Evidence Hierarchy
Summarizes existing research on a topic.
What do these levels mean? →Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-13234APA
Reiss, Allison B; Gulkarov, Shelly; Lau, Raymond; Klek, Stanislaw P; Srivastava, Ankita; Renna, Heather A; De Leon, Joshua. (2025). Weight Reduction with GLP-1 Agonists and Paths for Discontinuation While Maintaining Weight Loss.. Biomolecules, 15(3). https://doi.org/10.3390/biom15030408
MLA
Reiss, Allison B, et al. "Weight Reduction with GLP-1 Agonists and Paths for Discontinuation While Maintaining Weight Loss.." Biomolecules, 2025. https://doi.org/10.3390/biom15030408
RethinkPeptides
RethinkPeptides Research Database. "Weight Reduction with GLP-1 Agonists and Paths for Discontin..." RPEP-13234. Retrieved from https://rethinkpeptides.com/research/reiss-2025-weight-reduction-with-glp1
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.