Permeation Enhancer-based Ionogel Shows Remarkable Potential for Oral Insulin Delivery.
Quick Facts
What This Study Found
A choline decanoate-based ionic liquid gel formulation enabled sustained oral insulin absorption in vivo, showing promise for replacing insulin injections.
Key Numbers
Choline decanoate 1:2 ratio; gel-like rheology; slow in vitro dissolution; sustained in vivo insulin absorption.
How They Did This
Ionic liquid synthesis, rheological characterization, in vitro dissolution, and in vivo oral insulin absorption studies in animals.
Why This Research Matters
Oral insulin delivery has been a goal for decades. This gel-like formulation uses a permeation enhancer ionic liquid to overcome the gut absorption barrier for peptide drugs.
What This Study Doesn't Tell Us
Animal study. Bioavailability compared to injected insulin not quantified in abstract. Long-term GI safety of ionic liquid unknown. Scale-up challenges.
Trust & Context
- Original Title:
- Permeation Enhancer-based Ionogel Shows Remarkable Potential for Oral Insulin Delivery.
- Published In:
- Advanced healthcare materials, 14(20), e2500946 (2025)
- Authors:
- Raptis, Konstantinos, Heade, Joanne, Cunha, Cristiana, van de Weert, Marco, Saaby, Lasse, Rønholt, Stine, Nielsen, Hanne Mørck
- Database ID:
- RPEP-13206
Evidence Hierarchy
Tests effects in animals (usually mice or rats), not humans.
What do these levels mean? →Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-13206APA
Raptis, Konstantinos; Heade, Joanne; Cunha, Cristiana; van de Weert, Marco; Saaby, Lasse; Rønholt, Stine; Nielsen, Hanne Mørck. (2025). Permeation Enhancer-based Ionogel Shows Remarkable Potential for Oral Insulin Delivery.. Advanced healthcare materials, 14(20), e2500946. https://doi.org/10.1002/adhm.202500946
MLA
Raptis, Konstantinos, et al. "Permeation Enhancer-based Ionogel Shows Remarkable Potential for Oral Insulin Delivery.." Advanced healthcare materials, 2025. https://doi.org/10.1002/adhm.202500946
RethinkPeptides
RethinkPeptides Research Database. "Permeation Enhancer-based Ionogel Shows Remarkable Potential..." RPEP-13206. Retrieved from https://rethinkpeptides.com/research/raptis-2025-permeation-enhancerbased-ionogel-shows
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.