This record provides bibliographic details and links to the original research. An editorial study breakdown is not available.
What the researchers found
A choline decanoate-based ionic liquid gel formulation enabled sustained oral insulin absorption in vivo, showing promise for replacing insulin injections.
Why it matters
Oral insulin delivery has been a goal for decades. This gel-like formulation uses a permeation enhancer ionic liquid to overcome the gut absorption barrier for peptide drugs.
The numbers in context
Choline decanoate 1:2 ratio; gel-like rheology; slow in vitro dissolution; sustained in vivo insulin absorption.
How the study worked
Ionic liquid synthesis, rheological characterization, in vitro dissolution, and in vivo oral insulin absorption studies in animals.
Who was studied
Animals (species not specified in abstract)
What this study cannot tell us
Animal study. Bioavailability compared to injected insulin not quantified in abstract. Long-term GI safety of ionic liquid unknown. Scale-up challenges.
Read the original research
Permeation Enhancer-based Ionogel Shows Remarkable Potential for Oral Insulin Delivery.
Advanced healthcare materials, 14(20), e2500946
Citation
Raptis, Konstantinos; Heade, Joanne; Cunha, Cristiana; van de Weert, Marco; Saaby, Lasse; Rønholt, Stine; Nielsen, Hanne Mørck. (2025). Permeation Enhancer-based Ionogel Shows Remarkable Potential for Oral Insulin Delivery.. Advanced healthcare materials, 14(20), e2500946. https://doi.org/10.1002/adhm.202500946