Enhanced FGF21 Delivery via Neutrophil-Membrane-Coated Nanoparticles Improves Therapeutic Efficacy for Myocardial Ischemia-Reperfusion Injury.
Quick Facts
What This Study Found
Neutrophil-membrane-coated nanoparticles loaded with FGF21 reduced heart damage after ischemia-reperfusion in mice by targeting inflamed cardiac tissue.
Key Numbers
Neutrophil-membrane coated liposomal NPs with FGF21; tested in mouse ischemia-reperfusion model; improved cardiac outcomes vs uncoated NPs.
How They Did This
Nanoparticle fabrication, neutrophil membrane coating, characterization, and in vivo testing in mouse I/R injury model.
Why This Research Matters
FGF21 is a metabolic regulator (like GLP-1 drugs) that protects the heart. Wrapping it in neutrophil membranes helps it reach damaged heart tissue more effectively.
What This Study Doesn't Tell Us
Mouse model. Complex manufacturing process. Long-term safety of neutrophil-coated particles unknown. FGF21 may have off-target effects.
Trust & Context
- Original Title:
- Enhanced FGF21 Delivery via Neutrophil-Membrane-Coated Nanoparticles Improves Therapeutic Efficacy for Myocardial Ischemia-Reperfusion Injury.
- Published In:
- Nanomaterials (Basel, Switzerland), 15(5) (2025)
- Authors:
- Rao, Zhiheng, Tang, Yuli, Zhu, Jiamei, Lu, Zhenzhen, Chen, Zhichao, Wang, Jiaojiao, Bao, Yuxuan, Mukondiwa, Alan Vengai, Wang, Cong, Wang, Xiaojie, Luo, Yongde, Li, Xiaokun
- Database ID:
- RPEP-13204
Evidence Hierarchy
Tests effects in animals (usually mice or rats), not humans.
What do these levels mean? →Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-13204APA
Rao, Zhiheng; Tang, Yuli; Zhu, Jiamei; Lu, Zhenzhen; Chen, Zhichao; Wang, Jiaojiao; Bao, Yuxuan; Mukondiwa, Alan Vengai; Wang, Cong; Wang, Xiaojie; Luo, Yongde; Li, Xiaokun. (2025). Enhanced FGF21 Delivery via Neutrophil-Membrane-Coated Nanoparticles Improves Therapeutic Efficacy for Myocardial Ischemia-Reperfusion Injury.. Nanomaterials (Basel, Switzerland), 15(5). https://doi.org/10.3390/nano15050346
MLA
Rao, Zhiheng, et al. "Enhanced FGF21 Delivery via Neutrophil-Membrane-Coated Nanoparticles Improves Therapeutic Efficacy for Myocardial Ischemia-Reperfusion Injury.." Nanomaterials (Basel, 2025. https://doi.org/10.3390/nano15050346
RethinkPeptides
RethinkPeptides Research Database. "Enhanced FGF21 Delivery via Neutrophil-Membrane-Coated Nanop..." RPEP-13204. Retrieved from https://rethinkpeptides.com/research/rao-2025-enhanced-fgf21-delivery-via
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.