Cathelicidin-related antimicrobial peptide (CRAMP) is toxic during neonatal murine influenza virus infection.
Quick Facts
What This Study Found
In neonatal mice with influenza, the cathelicidin antimicrobial peptide CRAMP was harmful rather than protective. Mice lacking CRAMP had better survival after infection.
Key Numbers
3-day-old neonatal mice; CRAMP knockout mice had improved influenza survival; LGG treatment downregulated CRAMP expression.
How They Did This
Neonatal mouse influenza model comparing CRAMP-knockout and wild-type mice. LGG probiotic treatment. Transcriptional analysis.
Why This Research Matters
Cathelicidins are usually considered protective. This finding that they can be toxic in neonatal viral infections challenges assumptions about innate immune peptides.
What This Study Doesn't Tell Us
Mouse neonatal model. Neonatal mouse immunity differs substantially from human neonatal immunity. Single virus strain tested.
Trust & Context
- Original Title:
- Cathelicidin-related antimicrobial peptide (CRAMP) is toxic during neonatal murine influenza virus infection.
- Published In:
- Journal of immunology (Baltimore, Md. : 1950), 214(5), 1022-1031 (2025)
- Database ID:
- RPEP-13201
Evidence Hierarchy
Tests effects in animals (usually mice or rats), not humans.
What do these levels mean? →Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-13201APA
Rao, Abhishek S; Ugwu, Nneka; Onufer, Abigail P; Kumova, Ogan; Carey, Alison J. (2025). Cathelicidin-related antimicrobial peptide (CRAMP) is toxic during neonatal murine influenza virus infection.. Journal of immunology (Baltimore, Md. : 1950), 214(5), 1022-1031. https://doi.org/10.1093/jimmun/vkae053
MLA
Rao, Abhishek S, et al. "Cathelicidin-related antimicrobial peptide (CRAMP) is toxic during neonatal murine influenza virus infection.." Journal of immunology (Baltimore, 2025. https://doi.org/10.1093/jimmun/vkae053
RethinkPeptides
RethinkPeptides Research Database. "Cathelicidin-related antimicrobial peptide (CRAMP) is toxic ..." RPEP-13201. Retrieved from https://rethinkpeptides.com/research/rao-2025-cathelicidinrelated-antimicrobial-peptide-cramp
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.