This record provides bibliographic details and links to the original research. An editorial study breakdown is not available.
What the researchers found
In neonatal mice with influenza, the cathelicidin antimicrobial peptide CRAMP was harmful rather than protective. Mice lacking CRAMP had better survival after infection.
Why it matters
Cathelicidins are usually considered protective. This finding that they can be toxic in neonatal viral infections challenges assumptions about innate immune peptides.
The numbers in context
3-day-old neonatal mice; CRAMP knockout mice had improved influenza survival; LGG treatment downregulated CRAMP expression.
How the study worked
Neonatal mouse influenza model comparing CRAMP-knockout and wild-type mice. LGG probiotic treatment. Transcriptional analysis.
Who was studied
3-day-old neonatal mice with influenza infection
What this study cannot tell us
Mouse neonatal model. Neonatal mouse immunity differs substantially from human neonatal immunity. Single virus strain tested.
Read the original research
Cathelicidin-related antimicrobial peptide (CRAMP) is toxic during neonatal murine influenza virus infection.
Journal of immunology (Baltimore, Md. : 1950), 214(5), 1022-1031
Citation
Rao, Abhishek S; Ugwu, Nneka; Onufer, Abigail P; Kumova, Ogan; Carey, Alison J. (2025). Cathelicidin-related antimicrobial peptide (CRAMP) is toxic during neonatal murine influenza virus infection.. Journal of immunology (Baltimore, Md. : 1950), 214(5), 1022-1031. https://doi.org/10.1093/jimmun/vkae053