Acetaminophen's spinal-supraspinal analgesic synergy in mice was partially blocked by opioid antagonists, revealing that this common over-the-counter painkiller works partly through the endogenous opioid system.
Key findingAcetaminophen's spinal/supraspinal antinociceptive self-synergy was attenuated by opioid receptor antagonists in mice, demonstrating an opioid recepto
What the researchers found
Acetaminophen's spinal/supraspinal antinociceptive self-synergy was attenuated by opioid receptor antagonists in mice, demonstrating an opioid receptor component to acetaminophen's pain-relieving mechanism.
Why it matters
Relevant for opioid-peptides, pain, receptor-signaling.
How the study worked
animal-study study on opioid-peptides, pain.
What this study cannot tell us
See abstract.
How to read the evidence
preliminary evidence.
When this study was published
Published in 2004.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Opioid receptors and acetaminophen (paracetamol).
European journal of pharmacology, 503(1-3), 209-10
Citation
Raffa, Robert B; Walker, Ellen A; Sterious, Steven N. (2004). Opioid receptors and acetaminophen (paracetamol).. European journal of pharmacology, 503(1-3), 209-10.