Acetaminophen's Pain Relief Partly Works Through the Opioid System
Acetaminophen's spinal-supraspinal analgesic synergy in mice was partially blocked by opioid antagonists, revealing that this common over-the-counter painkiller works partly through the endogenous opioid system.
Quick Facts
What This Study Found
Acetaminophen's spinal/supraspinal antinociceptive self-synergy was attenuated by opioid receptor antagonists in mice, demonstrating an opioid receptor component to acetaminophen's pain-relieving mechanism.
Key Numbers
How They Did This
animal-study study on opioid-peptides, pain.
Why This Research Matters
Relevant for opioid-peptides, pain, receptor-signaling.
The Bigger Picture
Advances peptide research.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding Acetaminophen's spinal/supraspinal antinociceptive self-synergy was attenuated by opioid receptor antagonists in mice, demonstrating an opioid recepto
- Evidence Grade:
- preliminary evidence.
- Study Age:
- Published in 2004.
- Original Title:
- Opioid receptors and acetaminophen (paracetamol).
- Published In:
- European journal of pharmacology, 503(1-3), 209-10 (2004)
- Authors:
- Raffa, Robert B, Walker, Ellen A, Sterious, Steven N
- Database ID:
- RPEP-00963
Evidence Hierarchy
Tests effects in animals (usually mice or rats), not humans.
What do these levels mean? →Frequently Asked Questions
What was studied?
Acetaminophen's Pain Relief Partly Works Through the Opioid System
What was found?
Acetaminophen's spinal-supraspinal analgesic synergy in mice was partially blocked by opioid antagonists, revealing that this common over-the-counter painkiller works partly through the endogenous opioid system.
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Cite This Study
https://rethinkpeptides.com/research/RPEP-00963APA
Raffa, Robert B; Walker, Ellen A; Sterious, Steven N. (2004). Opioid receptors and acetaminophen (paracetamol).. European journal of pharmacology, 503(1-3), 209-10.
MLA
Raffa, Robert B, et al. "Opioid receptors and acetaminophen (paracetamol).." European journal of pharmacology, 2004.
RethinkPeptides
RethinkPeptides Research Database. "Opioid receptors and acetaminophen (paracetamol)." RPEP-00963. Retrieved from https://rethinkpeptides.com/research/raffa-2004-opioid-receptors-and-acetaminophen
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.