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Study breakdown

Endothelin B Receptor Activation Produces Pain Relief Through Endogenous Opioid Release

evidence
The takeaway

Peripheral endothelin B receptor agonists produced pain relief in mice through triggering endogenous opioid peptide release — another non-opioid drug that works by enlisting the body's own painkillers.

Key finding

Peripheral endothelin B receptor agonists produced pain relief in mice through triggering endogenous opioid peptide release — another non-opioid drug

What the researchers found

Peripheral endothelin B receptor agonists produced pain relief in mice through triggering endogenous opioid peptide release — another non-opioid drug that works by enlisting the body's own painkillers.

Why it matters

Relevant for peptide research.

How the study worked

research study.

What this study cannot tell us

See abstract.

How to read the evidence

emerging evidence.

When this study was published

Published in 2010.

The bigger picture

Advances peptide research.

Questions still open

  • Further research needed.

Common questions

What was studied?
Endothelin B Receptor Activation Produces Pain Relief Through Endogenous Opioid Release
What was found?
Peripheral endothelin B receptor agonists produced pain relief in mice through triggering endogenous opioid peptide release — another non-opioid drug that works by enlisting the body's own painkillers.

Read the original research

Peripheral endothelin B receptor agonist-induced antinociception involves endogenous opioids in mice.

Pain, 149(2), 254-262

Citation

Quang, Phuong N; Schmidt, Brian L. (2010). Peripheral endothelin B receptor agonist-induced antinociception involves endogenous opioids in mice.. Pain, 149(2), 254-262. https://doi.org/10.1016/j.pain.2010.02.009