Ghrelin and GHRP-6 restored gastric motor function in diabetic mice with gastroparesis, increasing gastric contractions and emptying rate — complementary evidence for GH secretagogue gastroparesis therapy.
Key findingGhrelin and GHRP-6 restored gastric contractile activity and emptying in diabetic gastroparesis mice, with effects mediated through smooth muscle and
What the researchers found
Ghrelin and GHRP-6 restored gastric contractile activity and emptying in diabetic gastroparesis mice, with effects mediated through smooth muscle and neural pathways — confirming GH secretagogues as gastroprokinetic agents for diabetic GI dysfunction.
Why it matters
Relevant for ghrp, neuropeptides, gut-healing, diabetes.
How the study worked
animal-study study.
What this study cannot tell us
See abstract.
How to read the evidence
preliminary evidence.
When this study was published
Published in 2008.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Gastric motor effects of ghrelin and growth hormone releasing peptide 6 in diabetic mice with gastroparesis.
World journal of gastroenterology, 14(9), 1419-24
Citation
Qiu, Wen-Cai; Wang, Zhi-Gang; Wang, Wei-Gang; Yan, Jun; Zheng, Qi. (2008). Gastric motor effects of ghrelin and growth hormone releasing peptide 6 in diabetic mice with gastroparesis.. World journal of gastroenterology, 14(9), 1419-24.