GM-CSF elicits antibodies to tumor-associated proteins when used as a prostate cancer vaccine adjuvant.
Quick Facts
What This Study Found
Antibody responses to 5680 peptides were detected only with GM-CSF as an adjuvant.
Key Numbers
How They Did This
The study evaluated sera from prostate cancer patients in four clinical trials, using a peptide array of 177,604 peptides.
Why This Research Matters
Understanding how GM-CSF influences antibody production can improve vaccine strategies for prostate cancer. This research suggests that antibody responses may not reliably indicate immune spread, prompting a reevaluation of assessment methods.
What This Study Doesn't Tell Us
The study focuses on antibody responses and does not assess T cell responses directly, which may provide a more accurate measure of immune spread.
Trust & Context
- Original Title:
- GM-CSF elicits antibodies to tumor-associated proteins when used as a prostate cancer vaccine adjuvant.
- Published In:
- Cancer immunology, immunotherapy : CII, 71(9), 2267-2275 (2022)
- Database ID:
- RPEP-06435
Evidence Hierarchy
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Cite This Study
https://rethinkpeptides.com/research/RPEP-06435APA
Potluri, Hemanth K; Ng, Tun L; Newton, Michael A; McNeel, Douglas G. (2022). GM-CSF elicits antibodies to tumor-associated proteins when used as a prostate cancer vaccine adjuvant.. Cancer immunology, immunotherapy : CII, 71(9), 2267-2275. https://doi.org/10.1007/s00262-022-03150-3
MLA
Potluri, Hemanth K, et al. "GM-CSF elicits antibodies to tumor-associated proteins when used as a prostate cancer vaccine adjuvant.." Cancer immunology, 2022. https://doi.org/10.1007/s00262-022-03150-3
RethinkPeptides
RethinkPeptides Research Database. "GM-CSF elicits antibodies to tumor-associated proteins when ..." RPEP-06435. Retrieved from https://rethinkpeptides.com/research/potluri-2022-gmcsf-elicits-antibodies-to
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.