Complete cyclotide profiling of Oldenlandia affinis revealed unexpected chemical diversity including modified, linear, and novel macrocyclic variants — expanding the cyclotide toolkit for drug scaffold applications.
Key findingComprehensive LC-MS profiling of O. affinis identified modified, linearized, and novel macrocyclic cyclotide variants beyond previously known members,
What the researchers found
Comprehensive LC-MS profiling of O. affinis identified modified, linearized, and novel macrocyclic cyclotide variants beyond previously known members, revealing unexpected chemical diversity in a single plant species for expanded drug scaffold options.
Why it matters
Relevant for cyclic-peptides, peptide-design.
How the study worked
in-vitro study on cyclic-peptides, peptide-design.
What this study cannot tell us
See abstract.
How to read the evidence
preliminary evidence.
When this study was published
Published in 2007.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
The cyclotide fingerprint in oldenlandia affinis: elucidation of chemically modified, linear and novel macrocyclic peptides.
Chembiochem : a European journal of chemical biology, 8(9), 1001-11
Citation
Plan, Manuel Rey R; Göransson, Ulf; Clark, Richard J; Daly, Norelle L; Colgrave, Michelle L; Craik, David J. (2007). The cyclotide fingerprint in oldenlandia affinis: elucidation of chemically modified, linear and novel macrocyclic peptides.. Chembiochem : a European journal of chemical biology, 8(9), 1001-11.