Anti-Hypertensive and Anti-Diabetic Peptides from Fermented Sheep Milk with Anti-Inflammatory Effects
Fermented sheep milk peptides showed 76% ACE inhibition and 70% anti-diabetic enzyme inhibition with additional anti-inflammatory activity.
Quick Facts
What This Study Found
Fermented sheep milk produced peptides with 76% ACE inhibition and ~70% anti-diabetic enzyme inhibition, plus anti-inflammatory properties confirmed in vitro.
Key Numbers
L. paracasei M11 fermentation. ACE inhibition 76.32%, alpha-amylase 70.13%, alpha-glucosidase 70.11%, lipase 68.22%. Max peptide 9.77 mg/mL at 2.5% inoculation, 48h.
How They Did This
In vitro enzyme inhibition, peptide purification and characterization, anti-inflammatory assays, and molecular docking studies.
Why This Research Matters
Dual anti-hypertensive and anti-diabetic activity with anti-inflammatory benefits from a single food source could support functional food development.
The Bigger Picture
Alongside study 191, this builds the case for fermented sheep milk as a multi-target functional food for metabolic syndrome.
What This Study Doesn't Tell Us
In vitro study — bioavailability, digestive stability, and in vivo efficacy are untested.
Questions This Raises
- ?How do these peptides compare to pharmaceutical ACE inhibitors in potency?
- ?Could a standardized fermented dairy product deliver consistent therapeutic doses?
Trust & Context
- Key Stat:
- 76.3% ACE inhibition Strongest enzyme inhibition observed from fermented sheep milk peptides in this study
- Evidence Grade:
- In vitro and computational study — demonstrates biological plausibility but lacks animal or human validation.
- Study Age:
- Published in 2025, complementing related work on sheep milk bioactive peptides.
- Original Title:
- Production and characterization of anti-hypertensive and anti-diabetic peptides from fermented sheep milk with anti-inflammatory activity: in vitro and molecular docking studies.
- Published In:
- Journal of the science of food and agriculture, 105(8), 4096-4120 (2025)
- Authors:
- Pipaliya, Rinkal(2), Basaiawmoit, Bethsheba(3), Sakure, Amar A(3), Maurya, Ruchika, Bishnoi, Mahendra, Kondepudi, Kanthi Kiran, Padhi, Srichandan, Rai, Amit Kumar, Liu, Zhenbin, Sarkar, Preetam, Hati, Subrota
- Database ID:
- RPEP-13061
Evidence Hierarchy
Frequently Asked Questions
Can fermented dairy lower blood pressure?
Lab studies show fermented sheep milk peptides strongly inhibit ACE (a blood pressure enzyme), but human clinical trials are needed to confirm this benefit.
Are these peptides anti-inflammatory too?
Yes — the study found anti-inflammatory activity in addition to the anti-hypertensive and anti-diabetic effects.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-13061APA
Pipaliya, Rinkal; Basaiawmoit, Bethsheba; Sakure, Amar A; Maurya, Ruchika; Bishnoi, Mahendra; Kondepudi, Kanthi Kiran; Padhi, Srichandan; Rai, Amit Kumar; Liu, Zhenbin; Sarkar, Preetam; Hati, Subrota. (2025). Production and characterization of anti-hypertensive and anti-diabetic peptides from fermented sheep milk with anti-inflammatory activity: in vitro and molecular docking studies.. Journal of the science of food and agriculture, 105(8), 4096-4120. https://doi.org/10.1002/jsfa.13617
MLA
Pipaliya, Rinkal, et al. "Production and characterization of anti-hypertensive and anti-diabetic peptides from fermented sheep milk with anti-inflammatory activity: in vitro and molecular docking studies.." Journal of the science of food and agriculture, 2025. https://doi.org/10.1002/jsfa.13617
RethinkPeptides
RethinkPeptides Research Database. "Production and characterization of anti-hypertensive and ant..." RPEP-13061. Retrieved from https://rethinkpeptides.com/research/pipaliya-2025-production-and-characterization-of
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.