Serum thymosin α 1 levels in patients with chronic inflammatory autoimmune diseases.

Serum thymosin alpha 1 levels are significantly reduced in patients with chronic inflammatory autoimmune diseases compared to healthy controls, with the lowest levels observed in psoriatic arthritis patients. Treatment with disease-modifying anti-rheumatic drugs plus steroids was associated with higher Tα1 levels than other treatments, although levels remained below those of healthy individuals.

The study analyzed serum Tα1 levels using ELISA in 120 healthy controls and 200 patients with psoriatic arthritis, rheumatoid arthritis, or systemic lupus erythematosus. Data were correlated with demographic and clinical characteristics, including treatment regimens.

Understanding Tα1 levels in autoimmune diseases could help clarify its role in immune regulation and inflammation, potentially guiding new therapeutic approaches or biomarkers for disease activity.

The study design and evidence strength are not specified, and the cross-sectional nature limits conclusions about causality. The sample size for some disease groups was relatively small, and treatment effects require further prospective validation.