This record provides bibliographic details and links to the original research. An editorial study breakdown is not available.
What the researchers found
Substance P stimulates melanogenesis in human melanocytes by increasing endothelin 1 (EDN1) secretion via endothelin-converting enzyme 1 (ECE1). EDN1 then activates its receptor EDNRB, leading to increased cAMP levels and activation of melanogenesis-related signaling pathways.
Why it matters
Understanding how Substance P regulates pigment production can help develop treatments for pigmentation disorders and improve management of wound-induced hyperpigmentation or pigmented scars.
How the study worked
Human melanocytes were treated with varying doses of Substance P in vitro. Gene and protein expression levels of melanogenesis-related factors, neurokinin 1 receptor, EDN1, and EDNRB were measured. siRNA knockdown experiments targeted ECE1, EDN1, and EDNRB to assess their roles in Substance P-induced pigmentation and EDN1 secretion.
What this study cannot tell us
The study was conducted in vitro using cultured human melanocytes, which may not fully replicate in vivo skin environment. The exact clinical relevance and effects in living organisms remain to be confirmed.
Read the original research
Substance P stimulates endothelin 1 secretion via endothelin-converting enzyme 1 and promotes melanogenesis in human melanocytes.
The Journal of investigative dermatology, 135(2), 551-559
Citation
Park, Phil June; Lee, Tae Ryong; Cho, Eun-Gyung. (2015). Substance P stimulates endothelin 1 secretion via endothelin-converting enzyme 1 and promotes melanogenesis in human melanocytes.. The Journal of investigative dermatology, 135(2), 551-559. https://doi.org/10.1038/jid.2014.423