Substance P stimulates endothelin 1 secretion via endothelin-converting enzyme 1 and promotes melanogenesis in human melanocytes.
Quick Facts
What This Study Found
Substance P stimulates melanogenesis in human melanocytes by increasing endothelin 1 (EDN1) secretion via endothelin-converting enzyme 1 (ECE1). EDN1 then activates its receptor EDNRB, leading to increased cAMP levels and activation of melanogenesis-related signaling pathways.
Key Numbers
How They Did This
Human melanocytes were treated with varying doses of Substance P in vitro. Gene and protein expression levels of melanogenesis-related factors, neurokinin 1 receptor, EDN1, and EDNRB were measured. siRNA knockdown experiments targeted ECE1, EDN1, and EDNRB to assess their roles in Substance P-induced pigmentation and EDN1 secretion.
Why This Research Matters
Understanding how Substance P regulates pigment production can help develop treatments for pigmentation disorders and improve management of wound-induced hyperpigmentation or pigmented scars.
What This Study Doesn't Tell Us
The study was conducted in vitro using cultured human melanocytes, which may not fully replicate in vivo skin environment. The exact clinical relevance and effects in living organisms remain to be confirmed.
Trust & Context
- Original Title:
- Substance P stimulates endothelin 1 secretion via endothelin-converting enzyme 1 and promotes melanogenesis in human melanocytes.
- Published In:
- The Journal of investigative dermatology, 135(2), 551-559 (2015)
- Authors:
- Park, Phil June, Lee, Tae Ryong, Cho, Eun-Gyung
- Database ID:
- RPEP-02763
Evidence Hierarchy
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Cite This Study
https://rethinkpeptides.com/research/RPEP-02763APA
Park, Phil June; Lee, Tae Ryong; Cho, Eun-Gyung. (2015). Substance P stimulates endothelin 1 secretion via endothelin-converting enzyme 1 and promotes melanogenesis in human melanocytes.. The Journal of investigative dermatology, 135(2), 551-559. https://doi.org/10.1038/jid.2014.423
MLA
Park, Phil June, et al. "Substance P stimulates endothelin 1 secretion via endothelin-converting enzyme 1 and promotes melanogenesis in human melanocytes.." The Journal of investigative dermatology, 2015. https://doi.org/10.1038/jid.2014.423
RethinkPeptides
RethinkPeptides Research Database. "Substance P stimulates endothelin 1 secretion via endothelin..." RPEP-02763. Retrieved from https://rethinkpeptides.com/research/park-2015-substance-p-stimulates-endothelin
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Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.