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Study breakdown

Stress-Induced Pain Relief Depends on Stress Duration: Different Timescales Activate Different Opioids

evidence
The takeaway

The duration of stress determined which endogenous opioid system mediated stress-induced analgesia — short stress used non-opioid mechanisms while prolonged stress recruited endogenous opioid peptide release.

Key finding

The duration of stress determined which endogenous opioid system mediated stress-induced analgesia — short stress used non-opioid mechanisms while pro

What the researchers found

The duration of stress determined which endogenous opioid system mediated stress-induced analgesia — short stress used non-opioid mechanisms while prolonged stress recruited endogenous opioid peptide release.

Why it matters

Relevant for peptide research.

How the study worked

research study.

What this study cannot tell us

See abstract.

How to read the evidence

emerging evidence.

When this study was published

Published in 2011.

The bigger picture

Advances peptide research.

Questions still open

  • Further research needed.

Common questions

What was studied?
Stress-Induced Pain Relief Depends on Stress Duration: Different Timescales Activate Different Opioids
What was found?
The duration of stress determined which endogenous opioid system mediated stress-induced analgesia — short stress used non-opioid mechanisms while prolonged stress recruited endogenous opioid peptide release.

Read the original research

Stress-induced analgesia and endogenous opioid peptides: the importance of stress duration.

European journal of pharmacology, 650(2-3), 563-7

Citation

Parikh, Drupad; Hamid, Abdul; Friedman, Theodore C; Nguyen, Khanh; Tseng, Andy; Marquez, Paul; Lutfy, Kabirullah. (2011). Stress-induced analgesia and endogenous opioid peptides: the importance of stress duration.. European journal of pharmacology, 650(2-3), 563-7. https://doi.org/10.1016/j.ejphar.2010.10.050