PYY3-36 modulated TSH (thyroid-stimulating hormone) secretion in rats, revealing a previously unknown connection between the gut satiety peptide system and thyroid regulation.
Key findingPYY3-36 modulated thyrotropin (TSH) secretion in rats through hypothalamic/pituitary pathways, revealing a novel gut peptide-thyroid axis connection —
What the researchers found
PYY3-36 modulated thyrotropin (TSH) secretion in rats through hypothalamic/pituitary pathways, revealing a novel gut peptide-thyroid axis connection — the satiety system influences thyroid function beyond just appetite control.
Why it matters
Relevant for neuropeptides, hormone-optimization.
How the study worked
animal-study study on neuropeptides, hormone-optimization.
What this study cannot tell us
See abstract.
How to read the evidence
preliminary evidence.
When this study was published
Published in 2006.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Peptide YY (PYY)3-36 modulates thyrotropin secretion in rats.
The Journal of endocrinology, 191(2), 459-63
Citation
Oliveira, K J; Paula, G S M; Costa-e-Sousa, R H; Souza, L L; Moraes, D C; Curty, F H; Pazos-Moura, C C. (2006). Peptide YY (PYY)3-36 modulates thyrotropin secretion in rats.. The Journal of endocrinology, 191(2), 459-63.