The tetrapeptide N-acetyl-Pro-Pro-Tyr-Leu in skin care formulations-Physicochemical and release studies.
Quick Facts
What This Study Found
The release rate of the tetrapeptide N-acetyl-Pro-Pro-Tyr-Leu is strongly influenced by the physicochemical properties of the skin care formulation, with higher viscosity semisolids exhibiting slower peptide permeation through membranes.
Key Numbers
How They Did This
The study prepared different skin care formulations containing the tetrapeptide, characterized their pH, viscosity, stability, and particle size, and calculated peptide diffusion parameters using the Einstein-Smoluchowski equation. Release kinetics were investigated through membrane penetration studies to determine release rate constants.
Why This Research Matters
Understanding how formulation properties affect peptide release helps optimize skin care products for better delivery and effectiveness of active peptides.
What This Study Doesn't Tell Us
The study did not specify in vivo skin penetration or clinical efficacy, and the exact study type and evidence strength were not provided.
Trust & Context
- Original Title:
- The tetrapeptide N-acetyl-Pro-Pro-Tyr-Leu in skin care formulations-Physicochemical and release studies.
- Published In:
- International journal of pharmaceutics, 492(1-2), 161-8 (2015)
- Authors:
- Olejnik, Anna, Schroeder, Grzegorz, Nowak, Izabela
- Database ID:
- RPEP-02758
Evidence Hierarchy
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Cite This Study
https://rethinkpeptides.com/research/RPEP-02758APA
Olejnik, Anna; Schroeder, Grzegorz; Nowak, Izabela. (2015). The tetrapeptide N-acetyl-Pro-Pro-Tyr-Leu in skin care formulations-Physicochemical and release studies.. International journal of pharmaceutics, 492(1-2), 161-8. https://doi.org/10.1016/j.ijpharm.2015.06.050
MLA
Olejnik, Anna, et al. "The tetrapeptide N-acetyl-Pro-Pro-Tyr-Leu in skin care formulations-Physicochemical and release studies.." International journal of pharmaceutics, 2015. https://doi.org/10.1016/j.ijpharm.2015.06.050
RethinkPeptides
RethinkPeptides Research Database. "The tetrapeptide N-acetyl-Pro-Pro-Tyr-Leu in skin care formu..." RPEP-02758. Retrieved from https://rethinkpeptides.com/research/olejnik-2015-the-tetrapeptide-nacetylproprotyrleu-in
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.