Complexes of Ghrelin GHS-R1a, GHS-R1b, and Dopamine D1 Receptors Localized in the Ventral Tegmental Area as Main Mediators of the Dopaminergic Effects of Ghrelin.
Quick Facts
What This Study Found
GHS-R1a:GHS-R1b:D1R oligomers are the main mediators of ghrelin's dopaminergic effects in the rodent VTA.
Key Numbers
How They Did This
The study used mammalian cell transfection, ex vivo experiments, in vivo microdialysis, and patch-clamp electrophysiology to analyze receptor interactions and effects.
Why This Research Matters
Understanding the role of ghrelin in dopamine signaling could provide insights into motivation and behavior, potentially informing treatments for related disorders.
What This Study Doesn't Tell Us
The study primarily involved rodent models, which may not fully replicate human physiology.
Trust & Context
- Original Title:
- Complexes of Ghrelin GHS-R1a, GHS-R1b, and Dopamine D1 Receptors Localized in the Ventral Tegmental Area as Main Mediators of the Dopaminergic Effects of Ghrelin.
- Published In:
- The Journal of neuroscience : the official journal of the Society for Neuroscience, 42(6), 940-953 (2022)
- Authors:
- Navarro, Gemma, Rea, William, Quiroz, César, Moreno, Estefanía, Gomez, Devan, Wenthur, Cody J, Casadó, Vicent, Leggio, Lorenzo, Hearing, Matthew C, Ferré, Sergi
- Database ID:
- RPEP-06393
Evidence Hierarchy
Read More on RethinkPeptides
Related articles coming soon.
Cite This Study
https://rethinkpeptides.com/research/RPEP-06393APA
Navarro, Gemma; Rea, William; Quiroz, César; Moreno, Estefanía; Gomez, Devan; Wenthur, Cody J; Casadó, Vicent; Leggio, Lorenzo; Hearing, Matthew C; Ferré, Sergi. (2022). Complexes of Ghrelin GHS-R1a, GHS-R1b, and Dopamine D1 Receptors Localized in the Ventral Tegmental Area as Main Mediators of the Dopaminergic Effects of Ghrelin.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 42(6), 940-953. https://doi.org/10.1523/JNEUROSCI.1151-21.2021
MLA
Navarro, Gemma, et al. "Complexes of Ghrelin GHS-R1a, GHS-R1b, and Dopamine D1 Receptors Localized in the Ventral Tegmental Area as Main Mediators of the Dopaminergic Effects of Ghrelin.." The Journal of neuroscience : the official journal of the Society for Neuroscience, 2022. https://doi.org/10.1523/JNEUROSCI.1151-21.2021
RethinkPeptides
RethinkPeptides Research Database. "Complexes of Ghrelin GHS-R1a, GHS-R1b, and Dopamine D1 Recep..." RPEP-06393. Retrieved from https://rethinkpeptides.com/research/navarro-2022-complexes-of-ghrelin-ghsr1a
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.