Opioid Peptide Structures in Membranes: How Shape Determines Receptor Activation
NMR studies of opioid peptides in membrane environments revealed conformations distinct from solution structures, providing the actual receptor-interacting shapes needed for drug design.
Quick Facts
What This Study Found
Opioid peptide conformations in membrane-mimetic environments differed significantly from solution structures, revealing the biologically relevant receptor-interacting conformations for structure-based opioid drug design.
Key Numbers
How They Did This
review study on opioid-peptides, peptide-design.
Why This Research Matters
Relevant for opioid-peptides, peptide-design, receptor-signaling.
The Bigger Picture
Advances peptide/biomarker research.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding Opioid peptide conformations in membrane-mimetic environments differed significantly from solution structures, revealing the biologically relevant rec
- Evidence Grade:
- moderate evidence.
- Study Age:
- Published in 2004.
- Original Title:
- Conformational analysis of opioid peptides in the solid states and the membrane environments by NMR spectroscopy.
- Published In:
- Current topics in medicinal chemistry, 4(1), 135-45 (2004)
- Authors:
- Naito, Aira, Nishimura, Katsuyuki
- Database ID:
- RPEP-00953
Evidence Hierarchy
Summarizes existing research on a topic.
What do these levels mean? →Frequently Asked Questions
What was studied?
Opioid Peptide Structures in Membranes: How Shape Determines Receptor Activation
What was found?
NMR studies of opioid peptides in membrane environments revealed conformations distinct from solution structures, providing the actual receptor-interacting shapes needed for drug design.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-00953APA
Naito, Aira; Nishimura, Katsuyuki. (2004). Conformational analysis of opioid peptides in the solid states and the membrane environments by NMR spectroscopy.. Current topics in medicinal chemistry, 4(1), 135-45.
MLA
Naito, Aira, et al. "Conformational analysis of opioid peptides in the solid states and the membrane environments by NMR spectroscopy.." Current topics in medicinal chemistry, 2004.
RethinkPeptides
RethinkPeptides Research Database. "Conformational analysis of opioid peptides in the solid stat..." RPEP-00953. Retrieved from https://rethinkpeptides.com/research/naito-2004-conformational-analysis-of-opioid
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.