Potential Molecular Targets for Treating Neuropathic Orofacial Pain Based on Current Findings in Animal Models.
Quick Facts
What This Study Found
CGRP receptor antagonists emerge as the most promising molecular target for neuropathic orofacial pain, with sufficient safety and mechanistic data for clinical translation.
Key Numbers
Models: PTNP (nerve trauma) and PTN (root compression); targets: CGRP, inflammation, ectopic discharges, neuron-glia interactions
How They Did This
Narrative review of animal models of post-traumatic trigeminal neuropathic pain (PTNP) and primary trigeminal neuralgia (PTN), and therapeutic candidates identified therein.
Why This Research Matters
Chronic face pain severely affects quality of life and has few effective treatments. Identifying validated molecular targets could lead to new therapies.
What This Study Doesn't Tell Us
Review of animal models. Pain mechanisms in animals may not perfectly represent human neuropathic pain. Clinical translation is not guaranteed.
Trust & Context
- Original Title:
- Potential Molecular Targets for Treating Neuropathic Orofacial Pain Based on Current Findings in Animal Models.
- Published In:
- International journal of molecular sciences, 22(12) (2021)
- Authors:
- Nagakura, Yukinori, Nagaoka, Shogo, Kurose, Takahiro
- Database ID:
- RPEP-05636
Evidence Hierarchy
Summarizes existing research on a topic.
What do these levels mean? →Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-05636APA
Nagakura, Yukinori; Nagaoka, Shogo; Kurose, Takahiro. (2021). Potential Molecular Targets for Treating Neuropathic Orofacial Pain Based on Current Findings in Animal Models.. International journal of molecular sciences, 22(12). https://doi.org/10.3390/ijms22126406
MLA
Nagakura, Yukinori, et al. "Potential Molecular Targets for Treating Neuropathic Orofacial Pain Based on Current Findings in Animal Models.." International journal of molecular sciences, 2021. https://doi.org/10.3390/ijms22126406
RethinkPeptides
RethinkPeptides Research Database. "Potential Molecular Targets for Treating Neuropathic Orofaci..." RPEP-05636. Retrieved from https://rethinkpeptides.com/research/nagakura-2021-potential-molecular-targets-for
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Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.