Thymosin β4 protects against aortic aneurysm via endocytic regulation of growth factor signaling.
Quick Facts
What This Study Found
Tβ4 regulates LRP1-mediated endocytosis of PDGFR-β to maintain vascular stability. Tβ4-null mice develop aortic aneurysms rescuable by imatinib.
Key Numbers
Tβ4-null: VSMC + elastin defects; enhanced PDGFR-β signaling; increased recycling, reduced lysosomal targeting of LRP1-PDGFR-β; imatinib rescue
How They Did This
Mouse genetic study (Tβ4-null mice). Angiotensin II-induced aneurysm model. In vitro endocytosis and signaling studies. Imatinib rescue experiment.
Why This Research Matters
LRP1 variants are linked to aortic aneurysm risk in humans. Understanding how Tβ4 regulates this system could lead to new prevention strategies.
What This Study Doesn't Tell Us
Mouse model. Angiotensin II-induced aneurysm may not fully represent human disease. Imatinib has significant side effects for chronic use.
Trust & Context
- Original Title:
- Thymosin β4 protects against aortic aneurysm via endocytic regulation of growth factor signaling.
- Published In:
- The Journal of clinical investigation, 131(10) (2021)
- Authors:
- Munshaw, Sonali, Bruche, Susann, Redpath, Andia N, Jones, Alisha, Patel, Jyoti, Dubé, Karina N, Lee, Regent, Hester, Svenja S, Davies, Rachel, Neal, Giles, Handa, Ashok, Sattler, Michael, Fischer, Roman, Channon, Keith M, Smart, Nicola
- Database ID:
- RPEP-05630
Evidence Hierarchy
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Cite This Study
https://rethinkpeptides.com/research/RPEP-05630APA
Munshaw, Sonali; Bruche, Susann; Redpath, Andia N; Jones, Alisha; Patel, Jyoti; Dubé, Karina N; Lee, Regent; Hester, Svenja S; Davies, Rachel; Neal, Giles; Handa, Ashok; Sattler, Michael; Fischer, Roman; Channon, Keith M; Smart, Nicola. (2021). Thymosin β4 protects against aortic aneurysm via endocytic regulation of growth factor signaling.. The Journal of clinical investigation, 131(10). https://doi.org/10.1172/JCI127884
MLA
Munshaw, Sonali, et al. "Thymosin β4 protects against aortic aneurysm via endocytic regulation of growth factor signaling.." The Journal of clinical investigation, 2021. https://doi.org/10.1172/JCI127884
RethinkPeptides
RethinkPeptides Research Database. "Thymosin β4 protects against aortic aneurysm via endocytic r..." RPEP-05630. Retrieved from https://rethinkpeptides.com/research/munshaw-2021-thymosin-4-protects-against
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.