Both acyl-ghrelin and des-acyl ghrelin inhibited fat cell lipolysis (fat breakdown) through a receptor different from the classical GHS-R1a, proving des-acyl ghrelin has metabolic activity through its own unknown receptor.
Key findingBoth ghrelin forms inhibited isoproterenol-induced lipolysis in rat adipocytes, with the effect NOT mediated by GHS-R1a (des-acyl ghrelin was equally
What the researchers found
Both ghrelin forms inhibited isoproterenol-induced lipolysis in rat adipocytes, with the effect NOT mediated by GHS-R1a (des-acyl ghrelin was equally effective) — demonstrating fat metabolism regulation through an unidentified non-GHS-R receptor.
Why it matters
Relevant for ghrp, weight-loss, receptor-signaling.
How the study worked
in-vitro study on ghrp, weight-loss.
What this study cannot tell us
See abstract.
How to read the evidence
preliminary evidence.
When this study was published
Published in 2004.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Ghrelin and des-acyl ghrelin both inhibit isoproterenol-induced lipolysis in rat adipocytes via a non-type 1a growth hormone secretagogue receptor.
European journal of pharmacology, 498(1-3), 27-35
Citation
Muccioli, Giampiero; Pons, Nicoletta; Ghè, Corrado; Catapano, Filomena; Granata, Riccarda; Ghigo, Ezio. (2004). Ghrelin and des-acyl ghrelin both inhibit isoproterenol-induced lipolysis in rat adipocytes via a non-type 1a growth hormone secretagogue receptor.. European journal of pharmacology, 498(1-3), 27-35.