Efficacy of Intranodal Neoantigen Peptide-pulsed Dendritic Cell Vaccine Monotherapy in Patients With Advanced Solid Tumors: A Retrospective Analysis.
Quick Facts
What This Study Found
Intranodal neoantigen DC vaccination showed clinical responses in some advanced cancer patients, with response dependent on immune activation rather than neoantigen number.
Key Numbers
N=17; intranodal ultrasound-guided injection; ELISpot monitoring; response dependent on immune activation, not neoantigen number
How They Did This
Retrospective analysis of 17 patients with treatment-resistant advanced cancers. Whole exome sequencing for neoantigen prediction. Peptide-pulsed autologous DCs injected into lymph nodes via ultrasound. ELISpot immune monitoring.
Why This Research Matters
Personalized cancer vaccines could help patients who have run out of other options. Intranodal delivery may improve immune responses.
What This Study Doesn't Tell Us
Retrospective analysis. Small sample (N=17). No control group. Heterogeneous cancer types. Not all patients responded.
Trust & Context
- Original Title:
- Efficacy of Intranodal Neoantigen Peptide-pulsed Dendritic Cell Vaccine Monotherapy in Patients With Advanced Solid Tumors: A Retrospective Analysis.
- Published In:
- Anticancer research, 41(8), 4101-4115 (2021)
- Authors:
- Morisaki, Takashi(2), Morisaki, Takafumi, Kubo, Makoto, Onishi, Hideya, Hirano, Tatsuya, Morisaki, Shinji, Eto, Masatoshi, Monji, Keisuke, Takeuchi, Ario, Nakagawa, Shinichiro, Tanaka, Hiroto, Koya, Norihiro, Umebayashi, Masayo, Tsujimura, Kenta, Yew, Poh Yin, Yoshimura, Sachiko, Kiyotani, Kazuma, Nakamura, Yusuke
- Database ID:
- RPEP-05628
Evidence Hierarchy
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-05628APA
Morisaki, Takashi; Morisaki, Takafumi; Kubo, Makoto; Onishi, Hideya; Hirano, Tatsuya; Morisaki, Shinji; Eto, Masatoshi; Monji, Keisuke; Takeuchi, Ario; Nakagawa, Shinichiro; Tanaka, Hiroto; Koya, Norihiro; Umebayashi, Masayo; Tsujimura, Kenta; Yew, Poh Yin; Yoshimura, Sachiko; Kiyotani, Kazuma; Nakamura, Yusuke. (2021). Efficacy of Intranodal Neoantigen Peptide-pulsed Dendritic Cell Vaccine Monotherapy in Patients With Advanced Solid Tumors: A Retrospective Analysis.. Anticancer research, 41(8), 4101-4115. https://doi.org/10.21873/anticanres.15213
MLA
Morisaki, Takashi, et al. "Efficacy of Intranodal Neoantigen Peptide-pulsed Dendritic Cell Vaccine Monotherapy in Patients With Advanced Solid Tumors: A Retrospective Analysis.." Anticancer research, 2021. https://doi.org/10.21873/anticanres.15213
RethinkPeptides
RethinkPeptides Research Database. "Efficacy of Intranodal Neoantigen Peptide-pulsed Dendritic C..." RPEP-05628. Retrieved from https://rethinkpeptides.com/research/morisaki-2021-efficacy-of-intranodal-neoantigen
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.