Weight Loss in Overweight Women Changes Gut Hormones — And Not Always Favorably for Keeping Weight Off
Weight loss in overweight women with or without PCOS altered postprandial ghrelin, CCK, and PYY profiles, but some hormonal changes (increased ghrelin, reduced PYY) could promote weight regain — the hormonal basis for yo-yo dieting.
Quick Facts
What This Study Found
Weight loss in overweight women modified gut hormone profiles: increased postprandial ghrelin (hunger) and reduced PYY satiety responses — hormonal changes that favor weight regain, explaining the biological basis of yo-yo dieting and weight loss plateau.
Key Numbers
How They Did This
clinical-trial study on neuropeptides, weight-loss.
Why This Research Matters
Relevant for neuropeptides, weight-loss, fertility.
The Bigger Picture
Advances peptide research.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding Weight loss in overweight women modified gut hormone profiles: increased postprandial ghrelin (hunger) and reduced PYY satiety responses — hormonal ch
- Evidence Grade:
- moderate evidence.
- Study Age:
- Published in 2007.
- Original Title:
- Postprandial ghrelin, cholecystokinin, peptide YY, and appetite before and after weight loss in overweight women with and without polycystic ovary syndrome.
- Published In:
- The American journal of clinical nutrition, 86(6), 1603-10 (2007)
- Authors:
- Moran, Lisa J, Noakes, Manny, Clifton, Peter M(3), Wittert, Gary A, Le Roux, Carel W, Ghatei, Mohammed A, Bloom, Stephen R, Norman, Robert J
- Database ID:
- RPEP-01269
Evidence Hierarchy
Frequently Asked Questions
What was studied?
Weight Loss in Overweight Women Changes Gut Hormones — And Not Always Favorably for Keeping Weight Off
What was found?
Weight loss in overweight women with or without PCOS altered postprandial ghrelin, CCK, and PYY profiles, but some hormonal changes (increased ghrelin, reduced PYY) could promote weight regain — the hormonal basis for yo-yo dieting.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-01269APA
Moran, Lisa J; Noakes, Manny; Clifton, Peter M; Wittert, Gary A; Le Roux, Carel W; Ghatei, Mohammed A; Bloom, Stephen R; Norman, Robert J. (2007). Postprandial ghrelin, cholecystokinin, peptide YY, and appetite before and after weight loss in overweight women with and without polycystic ovary syndrome.. The American journal of clinical nutrition, 86(6), 1603-10.
MLA
Moran, Lisa J, et al. "Postprandial ghrelin, cholecystokinin, peptide YY, and appetite before and after weight loss in overweight women with and without polycystic ovary syndrome.." The American journal of clinical nutrition, 2007.
RethinkPeptides
RethinkPeptides Research Database. "Postprandial ghrelin, cholecystokinin, peptide YY, and appet..." RPEP-01269. Retrieved from https://rethinkpeptides.com/research/moran-2007-postprandial-ghrelin-cholecystokinin-peptide
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.