Weight loss in overweight women with or without PCOS altered postprandial ghrelin, CCK, and PYY profiles, but some hormonal changes (increased ghrelin, reduced PYY) could promote weight regain — the hormonal basis for yo-yo dieting.
Key findingWeight loss in overweight women modified gut hormone profiles: increased postprandial ghrelin (hunger) and reduced PYY satiety responses — hormonal ch
What the researchers found
Weight loss in overweight women modified gut hormone profiles: increased postprandial ghrelin (hunger) and reduced PYY satiety responses — hormonal changes that favor weight regain, explaining the biological basis of yo-yo dieting and weight loss plateau.
Why it matters
Relevant for neuropeptides, weight-loss, fertility.
How the study worked
clinical-trial study on neuropeptides, weight-loss.
What this study cannot tell us
See abstract.
How to read the evidence
moderate evidence.
When this study was published
Published in 2007.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Postprandial ghrelin, cholecystokinin, peptide YY, and appetite before and after weight loss in overweight women with and without polycystic ovary syndrome.
The American journal of clinical nutrition, 86(6), 1603-10
Citation
Moran, Lisa J; Noakes, Manny; Clifton, Peter M; Wittert, Gary A; Le Roux, Carel W; Ghatei, Mohammed A; Bloom, Stephen R; Norman, Robert J. (2007). Postprandial ghrelin, cholecystokinin, peptide YY, and appetite before and after weight loss in overweight women with and without polycystic ovary syndrome.. The American journal of clinical nutrition, 86(6), 1603-10.