A Novel Dermorphin-Based Painkiller Recruits Endogenous Opioid Peptides for Enhanced Analgesia
A novel dermorphin tetrapeptide analog produced analgesia partly through triggering endogenous opioid peptide release, confirming the drug-endogenous peptide amplification principle for enhanced pain relief.
Quick Facts
What This Study Found
Amidino-TAPA, a novel dermorphin tetrapeptide analog, produced antinociception partly mediated by endogenous opioid peptide release (confirmed by antiserum blocking), extending the drug-endogenous amplification mechanism to a new opioid drug class.
Key Numbers
How They Did This
animal-study study on opioid-peptides, pain.
Why This Research Matters
Relevant for opioid-peptides, pain, peptide-design.
The Bigger Picture
Advances peptide research.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding Amidino-TAPA, a novel dermorphin tetrapeptide analog, produced antinociception partly mediated by endogenous opioid peptide release (confirmed by anti
- Evidence Grade:
- preliminary evidence.
- Study Age:
- Published in 2007.
- Original Title:
- Involvement of endogenous opioid peptides in the antinociception induced by the novel dermorphin tetrapeptide analog amidino-TAPA.
- Published In:
- European journal of pharmacology, 560(2-3), 150-9 (2007)
- Authors:
- Mizoguchi, Hirokazu(4), Watanabe, Chizuko(3), Watanabe, Hiroyuki(3), Moriyama, Kaori, Sato, Bunsei, Ohwada, Keiko, Yonezawa, Akihiko, Sakurada, Tsukasa, Sakurada, Shinobu
- Database ID:
- RPEP-01268
Evidence Hierarchy
Tests effects in animals (usually mice or rats), not humans.
What do these levels mean? →Frequently Asked Questions
What was studied?
A Novel Dermorphin-Based Painkiller Recruits Endogenous Opioid Peptides for Enhanced Analgesia
What was found?
A novel dermorphin tetrapeptide analog produced analgesia partly through triggering endogenous opioid peptide release, confirming the drug-endogenous peptide amplification principle for enhanced pain relief.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-01268APA
Mizoguchi, Hirokazu; Watanabe, Chizuko; Watanabe, Hiroyuki; Moriyama, Kaori; Sato, Bunsei; Ohwada, Keiko; Yonezawa, Akihiko; Sakurada, Tsukasa; Sakurada, Shinobu. (2007). Involvement of endogenous opioid peptides in the antinociception induced by the novel dermorphin tetrapeptide analog amidino-TAPA.. European journal of pharmacology, 560(2-3), 150-9.
MLA
Mizoguchi, Hirokazu, et al. "Involvement of endogenous opioid peptides in the antinociception induced by the novel dermorphin tetrapeptide analog amidino-TAPA.." European journal of pharmacology, 2007.
RethinkPeptides
RethinkPeptides Research Database. "Involvement of endogenous opioid peptides in the antinocicep..." RPEP-01268. Retrieved from https://rethinkpeptides.com/research/mizoguchi-2007-involvement-of-endogenous-opioid
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.