Spinal Mu-1 Opioid Receptors and Dynorphin B Together Mediate Pain Relief From a Novel Opioid
The antinociceptive effect of synthetic opioid Tyr-d-Arg-Phe-Sar involved both direct mu-1 receptor activation AND endogenous dynorphin B release at the spinal level — a dual-mechanism analgesic.
Quick Facts
What This Study Found
Tyr-d-Arg-Phe-Sar analgesia at the spinal level involved both direct mu-1 opioid receptor activation and endogenous dynorphin B release, with anti-dynorphin antibodies partially blocking the effect — confirming dual direct + endogenous amplification mechanism.
Key Numbers
How They Did This
animal-study study on opioid-peptides, pain.
Why This Research Matters
Relevant for opioid-peptides, pain.
The Bigger Picture
Advances peptide research.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding Tyr-d-Arg-Phe-Sar analgesia at the spinal level involved both direct mu-1 opioid receptor activation and endogenous dynorphin B release, with anti-dyn
- Evidence Grade:
- preliminary evidence.
- Study Age:
- Published in 2006.
- Original Title:
- Contribution of spinal mu(1)-opioid receptors and dynorphin B to the antinociception induced by Tyr-d-Arg-Phe-Sar.
- Published In:
- Peptides, 27(11), 2786-93 (2006)
- Authors:
- Mizoguchi, Hirokazu(4), Ito, Kanenori, Watanabe, Hiroyuki(3), Watanabe, Chizuko, Katsuyama, Sou, Fujimura, Tsutomu, Sakurada, Tsukasa, Sakurada, Shinobu
- Database ID:
- RPEP-01167
Evidence Hierarchy
Tests effects in animals (usually mice or rats), not humans.
What do these levels mean? →Frequently Asked Questions
What was studied?
Spinal Mu-1 Opioid Receptors and Dynorphin B Together Mediate Pain Relief From a Novel Opioid
What was found?
The antinociceptive effect of synthetic opioid Tyr-d-Arg-Phe-Sar involved both direct mu-1 receptor activation AND endogenous dynorphin B release at the spinal level — a dual-mechanism analgesic.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-01167APA
Mizoguchi, Hirokazu; Ito, Kanenori; Watanabe, Hiroyuki; Watanabe, Chizuko; Katsuyama, Sou; Fujimura, Tsutomu; Sakurada, Tsukasa; Sakurada, Shinobu. (2006). Contribution of spinal mu(1)-opioid receptors and dynorphin B to the antinociception induced by Tyr-d-Arg-Phe-Sar.. Peptides, 27(11), 2786-93.
MLA
Mizoguchi, Hirokazu, et al. "Contribution of spinal mu(1)-opioid receptors and dynorphin B to the antinociception induced by Tyr-d-Arg-Phe-Sar.." Peptides, 2006.
RethinkPeptides
RethinkPeptides Research Database. "Contribution of spinal mu(1)-opioid receptors and dynorphin ..." RPEP-01167. Retrieved from https://rethinkpeptides.com/research/mizoguchi-2006-contribution-of-spinal-mu1opioid
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.