This record provides bibliographic details and links to the original research. An editorial study breakdown is not available.
What the researchers found
Identified 19 in vitro metabolites of 4 GHRH analogs and developed an LC-MS/MS urine detection method meeting WADA's 1 ng/mL performance limit.
Why it matters
Athletes may use GHRH analogs to boost growth hormone. Better detection methods protect fair competition.
The numbers in context
4 analogs: sermorelin, tesamorelin, CJC-1295, CJC-1295 DAC; 19 metabolites; LOD ≤1 ng/mL; LC-MS/MS
How the study worked
In vitro metabolism studies of sermorelin, tesamorelin, CJC-1295, and CJC-1295 DAC. Synthesized and characterized 19 metabolites. Developed and validated LC-MS/MS detection method in fortified urine.
Who was studied
N/A (in vitro metabolism and fortified urine method development)
What this study cannot tell us
In vitro metabolism may not fully represent in vivo metabolism. Method validated in fortified (spiked) urine, not real doping samples. Real-world detection has not been demonstrated yet.
Read the original research
Advances in the detection of growth hormone releasing hormone synthetic analogs.
Drug testing and analysis, 13(11-12), 1871-1887
Citation
Memdouh, Siham; Gavrilović, Ivana; Ng, Kelsey; Cowan, David; Abbate, Vincenzo. (2021). Advances in the detection of growth hormone releasing hormone synthetic analogs.. Drug testing and analysis, 13(11-12), 1871-1887. https://doi.org/10.1002/dta.3183