Advances in the detection of growth hormone releasing hormone synthetic analogs.
Quick Facts
What This Study Found
Identified 19 in vitro metabolites of 4 GHRH analogs and developed an LC-MS/MS urine detection method meeting WADA's 1 ng/mL performance limit.
Key Numbers
4 analogs: sermorelin, tesamorelin, CJC-1295, CJC-1295 DAC; 19 metabolites; LOD ≤1 ng/mL; LC-MS/MS
How They Did This
In vitro metabolism studies of sermorelin, tesamorelin, CJC-1295, and CJC-1295 DAC. Synthesized and characterized 19 metabolites. Developed and validated LC-MS/MS detection method in fortified urine.
Why This Research Matters
Athletes may use GHRH analogs to boost growth hormone. Better detection methods protect fair competition.
What This Study Doesn't Tell Us
In vitro metabolism may not fully represent in vivo metabolism. Method validated in fortified (spiked) urine, not real doping samples. Real-world detection has not been demonstrated yet.
Trust & Context
- Original Title:
- Advances in the detection of growth hormone releasing hormone synthetic analogs.
- Published In:
- Drug testing and analysis, 13(11-12), 1871-1887 (2021)
- Database ID:
- RPEP-05603
Evidence Hierarchy
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-05603APA
Memdouh, Siham; Gavrilović, Ivana; Ng, Kelsey; Cowan, David; Abbate, Vincenzo. (2021). Advances in the detection of growth hormone releasing hormone synthetic analogs.. Drug testing and analysis, 13(11-12), 1871-1887. https://doi.org/10.1002/dta.3183
MLA
Memdouh, Siham, et al. "Advances in the detection of growth hormone releasing hormone synthetic analogs.." Drug testing and analysis, 2021. https://doi.org/10.1002/dta.3183
RethinkPeptides
RethinkPeptides Research Database. "Advances in the detection of growth hormone releasing hormon..." RPEP-05603. Retrieved from https://rethinkpeptides.com/research/memdouh-2021-advances-in-the-detection
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.