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Study breakdown

Self-Assembling Peptide Gels With Attached Growth Factors Support Liver Cell Function

evidence
The takeaway

Growth factors tethered to self-assembling peptide scaffolds synergistically improved liver cell function (DNA synthesis, albumin, urea) — combining biomaterial design with growth factor delivery for tissue engineering.

Key finding

Growth factors tethered to self-assembling peptide scaffolds synergistically improved liver cell function (DNA synthesis, albumin, urea) — combining b

What the researchers found

Growth factors tethered to self-assembling peptide scaffolds synergistically improved liver cell function (DNA synthesis, albumin, urea) — combining biomaterial design with growth factor delivery for tissue engineering.

Why it matters

Relevant for peptide research.

How the study worked

research study.

What this study cannot tell us

See abstract.

How to read the evidence

emerging evidence.

When this study was published

Published in 2010.

The bigger picture

Advances peptide research.

Questions still open

  • Further research needed.

Common questions

What was studied?
Self-Assembling Peptide Gels With Attached Growth Factors Support Liver Cell Function
What was found?
Growth factors tethered to self-assembling peptide scaffolds synergistically improved liver cell function (DNA synthesis, albumin, urea) — combining biomaterial design with growth factor delivery for tissue engineering.

Read the original research

Synergistic effects of tethered growth factors and adhesion ligands on DNA synthesis and function of primary hepatocytes cultured on soft synthetic hydrogels.

Biomaterials, 31(17), 4657-71

Citation

Mehta, Geeta; Williams, Courtney M; Alvarez, Luis; Lesniewski, Martha; Kamm, Roger D; Griffith, Linda G. (2010). Synergistic effects of tethered growth factors and adhesion ligands on DNA synthesis and function of primary hepatocytes cultured on soft synthetic hydrogels.. Biomaterials, 31(17), 4657-71. https://doi.org/10.1016/j.biomaterials.2010.01.138